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作品数：84被引量：285H指数：8
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相关领域：医药卫生更多>>
相关作者：朱小飞方忠宏袁倩倩马红武李旦更多>>
相关机构：复旦大学中国科学院天津工业生物技术研究所甘肃农业大学南昌大学更多>>
相关期刊：《Open Journal of Gastroenterology》《The Innovation》《World Journal of Critical Care Medicine》《Engineering》更多>>
相关基金：国家自然科学基金更多>>
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Development of multi-epitope mRNA vaccine against Clostridioides difficile using reverse vaccinology and immunoinformatics approaches被引量：1
《Synthetic and Systems Biotechnology》2024年第4期667-683,共17页Caixia Tan Yuanyuan xiao Ting Liu Siyao Chen Juan Zhou Sisi Zhang Yiran Hu Anhua Wu Chunhui Li 
upported by the National Key Research and Development Program of China[No.2022YFC2009801,No.2022YFC2009805];the Natural Science Foundation of Hunan Province[No.2021JJ31071];the Project program of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital)[No.2021KFJJ05];Health Development Research Center of the National Health Commission,"Evidence-based Evaluation and Demonstration Base Construction Project of Infection Control Measures in Healthcare Institutions"[No.CNHDRC-KJ-L-2020-53-04375];Scientific and technological personnel lifting Project in Hunan Province[No.2023 TJ-Z11].
Clostridioides difficile(C.difficile),as the major pathogen of diarrhea in healthcare settings,has become increasingly prevalent within community populations,resulting in significant morbidity and mortality.However,th...
关键词：Clotridioides difficile(C.difficile) mRNA vaccine IMMUNOINFORMATICS Reverse vaccinology(RV) Molecular docking Molecular dynamics(MD)simulation 
New Insights Into the Molecular Characteristics of Binary Toxin-Producing Clostridioides difficile Strains in China:A Comparative Genomics Study
《Infectious Microbes & Diseases》2024年第4期189-196,共8页Tao Wu Xiajing Bi Yuhong Zhao Tao Lv Yizheng Zhou Lisi Zheng Ping Shen Danhua Zhu Yunbo Chen 
supported by the Basic Public Welfare Research Program of Zhejiang Province(LGC20C010002);the National Nature Science Foundation of China(82073609)and Shandong Provincial Laboratory Project(SYS202202)。
Binary toxin(CDT)-producing Clostridioides difficile is associated with severe clinical symptoms and high mortality rates.However,the fundamental genomic factors that underpin the differentiated prevalence of CDT-prod...
关键词：Clostridioides difficile binary toxin-producing C.difficile PaLoc CdtLoc pangenome accessory genome wholegenome sequences 
PMN-MDSC:A Culprit Behind Immunosenescence and Increased Susceptibility to Clostridioides difficile Infection During Aging
《Engineering》2024年第11期59-73,共15页Jianmin Wu Ming Zhang Hao Zhang Mingxuan Sheng Jiazeng Sun Fang Wu Haina Gao Lishui Chen Zhili Li Qiyu Tian Longjiao Zhu Bing Fang 
supported by the National Key Research and Development Program of China(2022YFF1100504);the 111 project from the Education Ministry of China(B18053);the National Natural Science Foundation of China(32101938 and 32302758);the China Postdoctoral Science Foundation(2022M723422);the Postdoctoral Fellowship Program of CPSF(GZB20230848).
Susceptibility to pathogens in the elderly is heightened with age,largely because of immunosenescence.As an immune regulatory organ,bone marrow creates immune cells that move to other organs and tis-sues through the b...
关键词：PMN-MDSC IMMUNOSENESCENCE AGING Mass cytometry Clostridioides difficile 
Fight or flee,a vital choice for Clostridioides difficile
《mLife》2024年第1期14-20,共7页Ji Zeng Sshuying Fang Jinquan Guo Min Dong Guo-Bao Tian Liang Tao 
Clostridioides difficile is a leading cause of healthcare-associated infections,causing billions of economic losses every year.Its symptoms range from mild diarrhea to life-threatening damage to the colon.Transmission...
关键词：C.difficile SPORULATION TcdA TcdB toxin production 
Novel,non-colonizing,single-strain live biotherapeutic product ADS024 protects against Clostridioides difficile infection challenge in vivo
《World Journal of Gastrointestinal Pathophysiology》2023年第4期71-85,共15页Christopher K Murphy Michelle M O’Donnell James W Hegarty Sarah Schulz Colin Hill R Paul Ross Mary C Rea Ronald Farquhar Laurent Chesnel 
BACKGROUND The Centers for Disease Control and Prevention estimate that Clostridioides difficile(C.difficile)causes half a million infections(CDI)annually and is a major cause of total infectious disease death in the ...
关键词：Gut Single-strain live biotherapeutic product ADS024 Clostridioides difficile Clostridioides difficile challenge model Microbiota 
Manipulation of the intestinal microbiome-a slow journey to primetime被引量：1
《World Journal of Clinical Cases》2023年第21期4975-4988,共14页Ofra Kriger-Sharabi Stephen D H Malnick David Fisher 
The gut microbiota has important functions in the regulation of normal body functions.Alterations of the microbiota are being increasingly linked to various disease states.The microbiome has been manipulated via the a...
关键词：Gut microbiota Fecal microbiota transplantation Clostridoides difficile Metabolic associated fatty liver disease Irritable bowel syndrome Inflammatory bowel disease 
Comparison of Microdroplet Digital PCR Assays with Real-time Fluorescence Quantitative PCR for Clostridioides difficile Detection被引量：1
《Biomedical and Environmental Sciences》2023年第7期653-657,共5页YIN Cai Hong SONG Zhan Yun LIU Xing Xing WANG Xiao Mu WANG Ying GAO Cheng Cheng SONG Xiu Ling FENG Xin 
funded by the Scientific and Technological Research Project of Jilin Province[grant numbers:20220203146SF,YDZJ202302CXJD054,20210101365JC];the Health Commission of Jilin Province[grant number:2019Q011];the Development of Education in Jilin Province,China[grant number:JJKH20211220KJ].
Clostridioides difficile(C.difficile),is an anaerobic Gram-positive bacterium found in the human intestine.Prolonged use of antibacterial drugs can result in C.difficile infection(CDI)[1],which is one of the most impo...
关键词：INTESTINE DRUGS TEMPLATE 
Overview of current detection methods and microRNA potential in Clostridioides difficile infection screening
《World Journal of Gastroenterology》2023年第22期3385-3399,共15页Marco Bocchetti Maria Grazia Ferraro Federica Melisi Piera Grisolia Marianna Scrima Alessia Maria Cossu Tung On Yau 
Clostridioides difficile(formerly called Clostridium difficile,C.difficile)infection(CDI)is listed as an urgent threat on the 2019 antibiotic resistance threats report in the United States by the Centers for Disease C...
关键词：Clostridioides difficile MICRORNA DIAGNOSTIC PROGNOSTIC BIOMARKER 
Coexisting cytomegalovirus colitis in an immunocompetent patient with Clostridioides difficile colitis:A case report
《World Journal of Clinical Cases》2023年第10期2343-2348,共6页Jun Hyoung Kim Hee-Sung Kim Hye Won Jeong 
BACKGROUND Clostridioides difficile(C.difficile)colitis is one of the most common infections in hospitalized patients,characterized by fever and diarrhea.It usually improves after appropriate antibiotic treatment;if n...
关键词：CYTOMEGALOVIRUS Clostridioides difficile COINFECTION COLITIS IMMUNOCOMPETENT Case report 
Clostridioides difficile infection in patients with nonalcoholic fatty liver disease-current status被引量：1
《World Journal of Hepatology》2023年第2期208-215,共8页Yana V Kiseleva Roman V Maslennikov Aida N Gadzhiakhmedova Tatyana S Zharikova Dmitry V Kalinin Yury O Zharikov 
Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease,leading to fibrosis,cirrhosis and hepatocellular carcinoma and also associated with increased cardiovascular disease mortality.The pathog...
关键词：Nonalcoholic fatty liver disease Clostridioides difficile Clostridioides difficile colonization Clostridioides difficile infection Minireview 
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