Coexisting cytomegalovirus colitis in an immunocompetent patient with Clostridioides difficile colitis:A case report  

作　　者：Jun Hyoung Kim Hee-Sung Kim Hye Won Jeong 

机构地区：[1]Department of Internal Medicine,Chungbuk National University Hospital,Cheongju 28644,Chungbuk,South Korea [2]Department of Internal Medicine,Chungbuk National University College of Medicine,Cheongju 28644,Chungbuk,South Korea

出　　处：《World Journal of Clinical Cases》2023年第10期2343-2348,共6页世界临床病例杂志

摘　　要：BACKGROUND Clostridioides difficile(C.difficile)colitis is one of the most common infections in hospitalized patients,characterized by fever and diarrhea.It usually improves after appropriate antibiotic treatment;if not,comorbidities should be considered.Cytomegalovirus(CMV)colitis is a possible co-existing diagnosis in patients with C.difficile infection with poor treatment response.However,compared with immunocompromised patients,CMV colitis in immunocompetent patients is not well studied.CASE SUMMARY We present an unusual case of co-existing CMV colitis in an immunocompetent patient with C.difficile infection.An 80-year-old female patient was referred to the infectious disease department due to diarrhea,abdominal discomfort,and fever for 1 wk during her hospitalization for surgery.C.difficile toxin B polymerase chain reaction on stool samples was positive.After C.difficile infection was diagnosed,oral vancomycin treatment was administered.Her symptoms including diarrhea,fever and abdominal discomfort improved for ten days.Unfortunately,the symptoms worsened again with bloody diarrhea and fever.Therefore,a sigmoidoscopy was performed for evaluation,showing a longitudinal ulcer on the sigmoid colon.Endoscopic biopsy confirmed CMV colitis,and the clinical symptoms improved after using ganciclovir.CONCLUSION Co-existing CMV colitis should be considered in patients with aggravated C.difficile infection on appropriate treatment,even in immunocompetent hosts.

关 键 词：CYTOMEGALOVIRUS Clostridioides difficile COINFECTION COLITIS IMMUNOCOMPETENT Case report 

分 类 号：R574.62[医药卫生—消化系统]