Endonuclease modified comet assay for oxidative DNA damage induced by detection of genetic toxiants  

作　　者：赵健 

机构地区：[1]Key Lab Chem Safe & Health,Chin Dis Contr & Prev Center

出　　处：《China Medical Abstracts(Internal Medicine)》2014年第2期66-66,共1页中国医学文摘（内科学分册（英文版）

摘　　要：Objective The aim of this study was to investigate the use of the lesion-specific endonucleases-modifiedcomet assay for analysis of DNA,oxidation in cell lines.Methods DNA breaks and oxidative damage were evaluated by normal alkaline and formamidopyrimidine-DNAglycosylase(FPG)modified comet assays.Cytotoxicity was assessed by MTT method.The human bronchial epi-

关 键 词：COMET DNA BRONCHIAL alkaline assessed oxidative BREAKS OLIVE respective VINCRISTINE 

分 类 号：R36[医药卫生—病理学]