Regulation of cancer cell migration and invasion by sphingosine-1-phosphate  

作　　者：James R Van Brocklyn 

机构地区：[1]Department of Pathology,The Ohio State University Columbus,OH 43210, United States

出　　处：《World Journal of Biological Chemistry》2010年第10期307-312,共6页世界生物化学杂志（英文版）（电子版）

基　　金：Supported by R21 CA124685 from the National Cancer Institute;R01 NS41517 from the National Institute of Neurological Disorders and Stroke

摘　　要：Sphingosine-1-phosphate (S1P) is a bioactive sphingo-lipid that has been implicated in regulation of a number of cancer cell malignant behaviors, including cell proliferation, survival, chemotherapeutic resistance and angiogenesis. However, the effects of S1P on cancer cell migration, invasion and metastasis, are perhaps its most complex, due to the fact that, depending upon the S1P receptors that mediate its responses and the crosstalk with other signaling pathways, S1P can either positively or negatively regulate invasion. This review summarizes the effects of S1P on cancer cell invasion and the mechanisms by which it affects this important aspect of cancer cell behavior.Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that has been implicated in regulation of a number of cancer cell malignant behaviors, including cell proliferation, survival, chemotherapeutic resistance and angiogenesis. However, the effects of S1P on cancer cell migration, invasion and metastasis, are perhaps its most complex, due to the fact that, depending upon the S1P receptors that mediate its responses and the crosstalk with other signaling pathways, S1P can either positively or negatively regulate invasion. This review summarizes the effects of S1P on cancer cell invasion and the mechanisms by which it affects this important aspect of cancer cell behavior.

关 键 词：SPHINGOLIPIDS Cancer INVASION METASTASIS 

分 类 号：R730.2[医药卫生—肿瘤]