19个近交品系小鼠珠蛋白β肽谱的建立及遗传型的比较  

Comparative Study on Tryptic Peptide Mapping of Globin Beta Chains and the Genotype from Nineteen Inbred Strains of Mice

作　　者：宋树奎[1] 李建新[1] 胡开元[2] 

机构地区：[1]第二军医大学生物化学教研室,200433 [2]第二军医大学实验动物中心,200433

出　　处：《第二军医大学学报》1993年第1期14-19,共6页Academic Journal of Second Military Medical University

摘　　要：采用蛋白质细微结构分析技术,为BALB/c,BALB/cA,BALB/cJ,BALB/cJ-nu,BALB/nu/+,BALB/cyJax,B_(10),B_(10)A/sui,C_(57)BL/6,C_(57)BL/10snJ,SMMC/B,SMMC/C,C_3H/He,CFW,DBA/2,SWI,Swars/nu/+,SSB,129/sv等19个品近交小鼠建立了血红蛋白β肽链肽段图谱。结果表明,19个品系小鼠的β肽谱之间有明显差异,各自具有独特的β肽谱,这标志着不同品系小鼠各具特有的遗传型。这种遗传上的多态性可能是来自于某种交换过程。This study represents the first description of structural variations in the globin beta chains of 19 strains of inbred mice. The trypic pep tide mapping of beta chains of globin from BALB/c, BALB/cA, BALB/cJ, BALBcJ-nu, BALB/nu/ + ,BALB/cyJax,B10,B10A/sui,C57BL/6,C57BL/10snJ,SMMC/B,SMMC/C, C3H/He, CFW, DBA/2,SWI,Swars/nu/+,SSB and 129/sv strains of mice was established. The results showed that the position of peptide spots upon fingerprint mapping of beta chains was obviously different in comparison with each other. The different patterns of variability and polymorphism found in the various mouse species may then have come into being as a consequence of the action of selective forces on the various new beta chains which were created by some exchange processes.

关 键 词：珠蛋白 肽谱 遗传型 小鼠 

分 类 号：R394[医药卫生—医学遗传学]