注意缺陷多动障碍与多巴胺β羟化酶基因多态性的关系  

Association of dopamine β-hydroxylase polymorphism with attention deficit hyperactivity disorder in children

作　　者：张浩波[1] 王玉凤[1] 李君[1] 汪冰[1] 杨莉[1] 

机构地区：[1]北京大学精神卫生研究所,北京100083

出　　处：《北京大学学报（医学版）》2004年第3期290-293,共4页Journal of Peking University:Health Sciences

基　　金：科技部攀登计划基金资助项目 ( 95 -专 -0 9) ;卫生部临床学科重点项目 ( 2 0 0 1-3 2 1) ;北京大学人类疾病基因研究中心科研基金资助项目 ( 2 0 0 1 12 )~~

摘　　要：目的 :探讨注意力缺陷多动障碍 (ADHD)的不同亚型与多巴胺 β 羟化酶基因 (DBH) 5′侧翼区 10 2 1C→T多态的关系。方法 :以DSM Ⅳ诊断标准为依据 ,选择 2 92个ADHD汉族核心家系作为研究对象 ,采用以家系为基础的遗传统计学方法研究DBH 10 2 1C→T多态和ADHD各亚型之间的关系 ,并按照性别进行了分组比较。结果 :基于单体型的单体型相对危险度 (HHRR)结果显示DBH 10 2 1C→T多态与ADHD I(P =0 .0 6 7)和ADHD C(P =0 .0 76 )不存在传递不平衡 ,但有传递不平衡趋势。在男孩核心家系中 ,DBH 10 2 1C→T多态与ADHD C存在传递不平衡 (P =0 .0 4 ) ,T等位基因的RR =2 .0 11(P =0 .0 2 )。结论 :DBH基因与ADHD I、ADHD C存在关联趋势 ,与男孩ADHD C相关联。T等位基因为其危险因素。Objective: To study the association of dopamine β-hydroxylase gene 5′ flanking region polymorphism -1021 C→T with attention deficit hyperactivity disorder (ADHD) in Han children. Methods: ADHD was diagnosed according to the DSM-Ⅳ criteria . DNA was extracted and PCR was performed to examine the DBH-1021C→T polymorphism. HHRR was used to test the association of dopamine β-hydroxylase gene with different subtypes of ADHD. Results: HHRR results showed this polymorphism had a tendency to be associated with the inattention subtype (P=0.067) and the combined subtype (P=0.076). The T allele was the protective factor of the inattentive subtype (P= 0.07), and the risk factor of the combined subtype (P=0.08). After dividing the 292 nuclear families according to sex, DBH-1021C→T polymorphism was found to be associated with the combined subtype (P=0.04) with the T allele as the risk factor (P=0.02). There were no positive findings among the girl nuclear families of ADHD. Conclusion: DBH gene is related to ADHD combined subtype and inattention subtype. The genetic basis of ADHD combined subtype and is inattention is different, and is influenced by sex factor.

关 键 词：注意缺陷多动障碍 多巴胺Β羟化酶 基因多态性 ADHD 遗传学 精神卫生 

分 类 号：R749.94[医药卫生—神经病学与精神病学]