苏州地区健康人群β-纤维蛋白原455G/A、-148C/T基因多态性频率及与血浆纤维蛋白原水平的关系  

The Study of beta-Fibrinogen Gene -455G/A, -148C/T Polymorphisms and their Association with Plasma Fibrinogen Levels in Health Population in Suzhou

作　　者：霍红梅[1] 张志琳[1] 钱建军[1] 

机构地区：[1]苏州大学附属第二医院神经内科,江苏苏州215004

出　　处：《中国血液流变学杂志》2004年第4期460-462,共3页Chinese Journal of Hemorheology

摘　　要：目的　调查分析苏州地区健康人群 β 纤维蛋白原 4 5 5G/A、 14 8C/T基因位点的多态性分布情况。 方法　用clauss法测定血浆纤维蛋白原浓度 ,应用多聚酶链反应限制性酶切法 ,分析 10 2名健康人DNA样品的基因型 ,计算等位基因频率。结果　Fgβ 4 5 5G/A多态性中 ,突变位点A等位基因频率为 0 .186 ,β 14 8C/T多态性中 ,T等位基因频率为 0 .2 0 6。A或T基因携带者血浆Fg水平明显高于非携带者。结论　苏州地区人群Fg等位基因频率低于广东地区。β 4 5 5G/A、β 14 8C/T基因多态性与血浆Fg水平相关。Objective To investigate frequencies of beta-fibrinogen (Fg ) gene -455G/A, -148C/T polymorphisms in health population in Suzhou.Methods The Fg β gene -455G/A and -148C/T polymorphisms of 102 health individuals in Suzhou were analyzed by restriction fragment length polymorphisms. Plasma fibrinogen levels were determined by clauss method.Results The frequencies of -455A allele and -148 T allele were 0.186、0.206, respectively. The plasma fibrinogen levels of these with the mutant gene were significantly higher than those without these genes. Conclusion The frequency of Fg gene -455G/A、-148C/T polymorphisms in health population in Suzhou was lower than that of in Guangdong. Fg gene -455G/A、-148C/T polymorphisms were associated with plasma fibrinogen level.

关 键 词：血浆纤维蛋白原 健康人群 基因多态性 Β纤维蛋白原 等位基因频率 苏州地区 基因携带者 β-1 限制性酶切 水平 

分 类 号：R743[医药卫生—神经病学与精神病学] R446[医药卫生—临床医学]