268对流产夫妇的染色体分析  

The chromosome analysis of 268 abortioncouples

作　　者：邹玉兰[1] 王家鼎[1] 张文勤[1] 赵淑春[1] 侯小丽[1] 何宝凤 

机构地区：[1]沈阳市计划生育科研所,沈阳市计划生育委员会

出　　处：《中国优生与遗传杂志》1994年第F08期90-92,共3页Chinese Journal of Birth Health & Heredity

摘　　要：我室自１９８５年１月至１９８９年１０月对２６８对流产夫妇的染色体核型作了细胞遗传学研究，结果发现异常２３例（女１７例、男６例）异常发生率为４．３％，其中平衡易位１９例（相互易位１７例、罗伯逊易位２例）占３．５％（１９／５３６），占异常总数８３％，臂间倒位２例，占０．４％（２／５３６）。占异常总数８．７％，性染色体嵌合型３例，占０．６％（３／５３６），占异常总数１３％。异常核型涉及的染色体有１、２、３、４、５、７、８、９、１０、１１、１２、１３、１４、１５、１６、１７、２１、２２、Ｘ共１９条。A large study material have given indication that abnormal chromosomes,particulerly balanced translocation wouldbe that factor of abortion,stillbirth,Stillborn foetus,aberration foetus.Butthe carriers in normal phenotype. In or-der to go further into this question,wehave checked the karyotype of 268 abor-tion couples.We have found abnormalkaryotype 23(23/536 17 women, 6 men)There are 19 balanced translocation carri-ers(19/536) 2 Robertsonian transloca-tion. 17 reciprocal translocation)2 per-centric inversion carriers(2/536),3 sexchromosomal mosaictype carriers(3/536)Abnormal chromosomes tevolve thechromosome1.2.3.4.5.7.8.9.10.11.12.13.14.15.16.17.21.22.X(in all 19 chromosomes)In the course of the counseling.forthe couples who have even borno theabortion.stillbirth foetus.aberrationfoetus.We should give them to make thechromosmes checking and direct thempregnancy ,so that we can enhance thequality of fature generations.

关 键 词：夫妇 染色体分析 流产 总数 异常 臂间倒位 细胞遗传学研究 对流 意义 发现 

分 类 号：R714[医药卫生—妇产科学] R221.1[医药卫生—临床医学]