Tumor Angiogenesis Correlated with bFGF and FGFR-1 in Lung Cancer  

碱性成纤维细胞生长因子及其受体与肺癌新生血管(英文)

作　　者：周涛[1] 潘铁成[1] 

机构地区：[1]武汉华中科技大学同济医学院附属同济医院胸心外科,430030

出　　处：《The Chinese-German Journal of Clinical Oncology》2005年第2期93-98,共6页中德临床肿瘤学杂志（英文版）

摘　　要：To study the relationship between angiogenesis and the expression of bFGF andFGFR-1 in lung cancer. Methods: The specimens of 56 patients with lung cancer treated with surgerywere collected. Anti-Von Willebrand factor antibody was used to measure microvascular density (MVD)by means of SABC immunohistochemical technique, and antibody to basic fibroblast growth factor(bFGF) and its receptor (FGFR-1) to detect the expression of these three proteins in the tumortissues. The survival time was compared between low MVD and high MVD groups by the Kaplan-Meiermethod. Results: (1) The expression of MVD showed no significant difference in some clinicalcharacteristics, including sex, age, T stage, M stage and pathologic type, but significantdifference in N stage (P 【 0.01) and clinical stage (P 【 0.05). (2) Survival analysis showed thathigh MVD group was associated with a risk of death (P 【 0.01). (3) The expression of bFGF and FGFR-1were both related to lymphatic metastasis and clinical staging (P 【 0.05). (4) Significantdifference was seen between low MVD and high MVD groups in the bFGF expression in lung cancer (P 【0.01), whereas no correlation in FGFR-1. (5) High co-expression of bFGF and FGFR-1 was consistent intumor cells. Conclusion: (1) MVD is a good prognostic factor for patients of lung cancer, and thesame as bFGF. (2) The angiogenesis may be induced after bFGF binding to FGFR-1.

关 键 词：basic fibroblast growth factor FGFR-1 lung cancer ANGIOGENESIS microvascular density 

分 类 号：R734.2[医药卫生—肿瘤]