急性脑缺血再灌流后脑组织钙依赖中性蛋白酶的变化  

Change in the Brain Calpains Activity Following Acute Cerebral Ischemia in Rat

作　　者：彭凯润[1] 张幸运[1] 石尚金[1] 张松[1] 

机构地区：[1]广州军区广州总医院神经内科,510010

出　　处：《临床神经科学》1994年第4期218-220,共3页Chinese Journal of Clinical Neurosciences

摘　　要：本文采用大鼠全脑缺血模型,观测脑缺血再灌流脑组织Ca^(2+)依赖性中性蛋白酶(calci-um-activated neutral proteinase,calpain)活性的变化及海马C_(A1)区神经元损害改变。结果显示脑缺血再灌流脑组织calpain Ⅰ和calpain Ⅱ活性都明显升高(P<0.01),C_(A1)区神经元密度相应下降,提示calpains在脑缺血损害过程中可能起一定作用。We have investigated the changes of calcium-activated neutral proteinases (calpains) activity during reperfusion after transient cerebral ischemia by using the four-vessel occlusion model of ischemia in rat. The results indicated that calpain I and calpain I activities increased significantly and neuronal density of the CAI region of the hippocampus decreased correspondently. It is concluded that calpains may be responsible for ischemic damage to the brain.

关 键 词：脑组织 再灌流 钙依赖性 中性蛋白酶 脑缺血 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]