合成肽核酸单体组氨酸的保护策略  

Protecting Tactics of Histidine in Synthesis of Peptide Nucleic Acid Monomer

作　　者：孟庆国[1] 赵风兰[1] 姜乃才[1] 

机构地区：[1]烟台大学药学院,山东烟台264005

出　　处：《烟台大学学报（自然科学与工程版）》2005年第4期287-292,共6页Journal of Yantai University(Natural Science and Engineering Edition)

摘　　要：以L-组氨酸为起始原料,设计合成了含组氨酸残基的手性肽核酸单体.以叔丁氧羰基(Boc)保护α-氨基,羧基形成苄酯加以保护,分别以苄氧羰基(Cbz)及2,4-二硝基苯基(Dnp)作为咪唑基的临时和永久保护基,共九步反应,手性肽核酸单体总收率13.3%.A chiral PNA monomer containing histidine residue has been designed and synthesized in 9 steps with an overall yield 13.3%. The protecting groups of a-amine, carboxyl, and imidazole are t-butyloxocarbonyl, benzyl, and benzyloxocarbonyl, respectively. The final protecting group of imidazole is 2,4-dinitrofluorobenzenyl （Dnp）.

关 键 词：肽核酸单体合成 组氨酸 保护策略 2 4-二硝基苯基 

分 类 号：R914[医药卫生—药物化学]