Synthesis and Biological Evaluation of a New Category of Purine-Nucleoside Analogues  

作　　者：李达谅 鲍红丽 谭启涛 柯玉萍 尤田耙 

机构地区：[1]Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China

出　　处：《Chinese Journal of Chemistry》2005年第12期1659-1664,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20172049）.

摘　　要：Convenient procedure for coupling of 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose and 4-nitroimidazole was provided to obtain β-anomer as major product. A novel category of nucleoside analogues with an imidazole base moiety bearing amino-acid residue was designed and synthesized to develop selective and effective antiviral agents. They were evaluated for the anti-HBV activity.Convenient procedure for coupling of 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose and 4-nitroimidazole was provided to obtain β-anomer as major product. A novel category of nucleoside analogues with an imidazole base moiety bearing amino-acid residue was designed and synthesized to develop selective and effective antiviral agents. They were evaluated for the anti-HBV activity.

关 键 词：ANTIVIRAL PURINE NUCLEOSIDE RIBAVIRIN amino acid GLYCOSIDATION 

分 类 号：O626.26[理学—有机化学]