Synthesis and Characterization of PEG-scuteilarin Conjugates,a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin  

Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin

作　　者：Qing Song ZHOU Xue Hua JIANG Jia Rui YU Ke Jia LI 

机构地区：[1]West China School of Pharmacy, Sichuan University, Chengdu 610041

出　　处：《Chinese Chemical Letters》2006年第1期85-88,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.30070935,30271614)

摘　　要：Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol （PEG） were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scuteUarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scuteUarin.Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol （PEG） were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scuteUarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scuteUarin.

关 键 词：SCUTELLARIN PEGYLATION PRODRUG physicochcmical properties stability. 

分 类 号：R284[医药卫生—中药学]