SCUTELLARIN

作品数：38被引量：162H指数：7
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相关领域：医药卫生化学工程更多>>
相关作者：黄照昌蔡佳黄建明郁韵秋李妮更多>>
相关机构：华中科技大学昆明制药集团股份有限公司复旦大学四川大学更多>>
相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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KEAP1 inhibitor-scutellarin-based liposomes serve as an antioxidant switch foroxidative stress induced by ischemic stroke injury
《Traditional Medicine Research》2025年第4期11-20,共10页Kai-Rui Liu Jun-Li Ba Yun Wang Sheng-Tao Hu Lu Gao Xiao-Ning Gao Chang-Hua Kou Jun Kang 
Medical andHealth Project (2023, No. KC23178).
Background:Ischemic stroke is a disease characterized by the damage of brain tissue due to insufficient blood supply.The neuronal necrosis caused by oxidative stress during the acute phase of ischemic stroke leads to ...
关键词：oxidative stress SCUTELLARIN liposomes KEAP1 NRF2 
Scutellarin alleviates liver injury in type 2 diabetic mellitus by suppressing hepatocyte apoptosis in vitro and in vivo
《Chinese Herbal Medicines》2023年第4期542-548,共7页Xiaoming Fan Yiyu Wang Xifan Li Taiqing Zhong Chunlan Cheng Yunfei Zhang 
funded by Science and Technology Base and Talent Project of Guangxi Autonomous Region (No. 2020AC20022);2022 Guilin Self-funded Science and Technology Project (No. 20220129z);2020 Research Basic Ability Improvement Project of Young and Middle-aged Teachers in Colleges or Universities in Guangxi (No. 2020KY12013)。
Objective: Scutellarin is a primary active composition come from Erigeron breviscapus. It is well known that scutellarin has anti-infammatory and antioxidant physiological functions. In this study, we detected the eff...
关键词：APOPTOSIS hepatocyte cells liver failure SCUTELLARIN type 2diabetic mellitus 
Scutellarin attenuates microglia activation in experimentally induced hypoxia-ischemia brain damage by down-regulating miRNA-7036a
《Acta Biochimica et Biophysica Sinica》2023年第10期1685-1688,共4页Wenji Jia Yun Yuan Li Yang Chunyun Wu 
supported by the grants from the National Natural Science Foundation of China(No.81960223 to C.W.);Applied Basic Research Projects of Yunnan Province(No.202001AY070001-217 to W.J.).
Neonatal hypoxic-ischemic encephalopathy(HIE)is widely acknowledged to cause acute neonatal death and chronic neurological injury[1].Currently,there is no effective treatment for neonatal hypoxia-ischemia brain damage...
关键词：damage ISCHEMIA HIE 
Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT,p38 MAPK/NF-κB pathways被引量：11
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第7期617-631,共15页Xiao ZHANG Zhicheng DONG Hui FAN Qiankun YANG Guili YU Enzhuang PAN Nana HE Xueqing LI Panpan ZHAO Mian FU Jingquan DONG 
supported by the Basic Science(Natural Science)Research Project of Higher Education of Jiangsu Province(Nos.21KJB230001 and 21KJB350019);the Open Foundation of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(No.HY202101);the Postdoctoral Science Foundation of Lianyungang(No.LYG20220013);the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
Alcoholic liver disease(ALD)is the most frequent liver disease worldwide,resulting in severe harm to personal health and posing a serious burden to public health.Based on the reported antioxidant and anti-inflammatory...
关键词：SCUTELLARIN Oxidative stress Alcoholic liver disease INFLAMMATION 
Scutellarin alleviates complete freund’s adjuvant-induced rheumatoid arthritis in mice by regulating the Keap1/Nrf2/HO-1 pathway
《BIOCELL》2023年第6期1307-1316,共10页JIAN LI QINGQING WANG XIAOYING ZHANG 
Scutellarin(SCU)is a herbal flavonoid glucuronide with multiple pharmacological activities,including antioxidant,anti-inflammation,vascular relaxation,anti-platelet,and myocardial protection.However,the effect of SCU ...
关键词：SCUTELLARIN Rheumatoid arthritis Th1/Th2 balance Keap1/Nrf2/HO-1 pathway Immunosuppression 
Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown被引量：4
《Acta Pharmacologica Sinica》2022年第10期2666-2677,共12页Xi-yu Mei Jing-nan Zhang Wang-ya Jia Bin Lu Meng-na Wang Tian-yu Zhang Li-li Ji 
The authors thank Prof.Zi-jia Zhang(Shanghai University of Traditional Chinese Medicine,Shanghai)for kindly gifting MDA-MB-231 cells;This work was financially supported by National Natural Science Foundation of China(82074084);the leadership in Science and Technology innovation of the third batch of national“Ten Thousand People Plan”for LLJ.
Triple-negative breast cancer(TNBC)is an aggressive subtype of breast cancer with high vascularity and frequent metastasis.Tumor-associated abnormal vasculature was reported to accelerate TNBC metastasis.Scutellarin(S...
关键词：TNBC metastasis endothelial barrier breakdown TNFΑ SCUTELLARIN 
Metabolic engineering of Yarrowia lipolytica for scutellarin production被引量：2
《Synthetic and Systems Biotechnology》2022年第3期958-964,共7页Yina Wang Xiaonan Liu Bihuan Chen Wei Liu Zhaokuan Guo Xiangyu Liu Xiaoxi Zhu Jiayu Liu Jin Zhang Jing Li Lei Zhang Yadi Gao Guanghui Zhang Yan Wang MIqbal Choudhary Shengchao Yang Huifeng Jiang 
funding from the Major Science and Technique Programs in Yunnan Province(No.2019ZF011-1);the National Natural Science Foundation of China(No.81960689);the National Key R&D Program of China(2020YFC1316400);the Project of Young and Middle-Aged Talent of Yunnan Province(No.2019HB019);Science and Technology Innovation team of Yunnan(No.202105AE160011);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-KJGG-002-02);the Tianjin Science Fund for Distinguished Young Scholars(No.18JCJQJC48300).
Scutellarin related drugs have superior therapeutic effects on cerebrovascular and cardiovascular diseases.Here,an optimal biosynthetic pathway for scutellarin was constructed in Yarrowia lipolytica platform due to it...
关键词：SCUTELLARIN Yarrowia lipolytica Metabolic engineering Combinatorial gene overexpression 
Ameliorative effect of scutellarin on acute alcohol brain injury in mice被引量：4
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第3期258-264,共7页Tianmeng ZHANG Kun WANG Hui FAN Qiankun YANG Xiao ZHANG Feixue LIU Xin FENG Yi CHEN Daoyang TENG Panpan ZHAO Jingquan DONG 
This work was supported by the Basic Science(Natural Science)Research Project of Higher Education of Jiangsu Province(No.21KJB230001);the Open Foundation of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(No.HY202101);the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
Drinking culture has high significance in both China and the world,whether in the entertainment sector or in social occasions;according to the World Health Organization's 2018 Global Alcohol and Health Report,about 3 ...
关键词：ALCOHOL INFLAMMATION EFFECT 
Scutellarin Reduces Cerebral Ischemia Reperfusion Injury Involving in Vascular Endothelium Protection and PKG Signal被引量：2
《Natural Products and Bioprospecting》2021年第6期659-670,共12页Ya-Juan Chen Chen Chen Meng-Yuan Li Qing-Qing Li Xiu-Juan Zhang Rong Huang Xing-Wei Zhu Chun-Yun Bai Liu-Yi Zhang Pei-Hua Peng Wei-Min Yang 
the National Natural Science Foundation of China(Nos.81560589,30960450,81173110 and 81560072);Yunnan Provincial Science and Technology Department(Nos.202105AF150015,202102AA310030,2018FE001(-026),2017FE467(-019),2014BC012,and 2017IC041);Yunnan Provincial Educational Department(Nos.2018JS161).
Flavonoid glycoside scutellarin(SCU)has been widely applied in the treatment of cerebral ischemic diseases in China.In this article,we conducted research on the working mechanisms of SCU in hypoxia reoxygenation(HR)in...
关键词：SCUTELLARIN Basilar artery Vascular endothelium Ischemia reperfusion PKG 
Suppression of AOM/DSS-induced colorectal cancer by scutellarin through downregulation of Wnt signaling pathway activity
《中国药理学与毒理学杂志》2021年第10期739-740,共2页ZENG Sha ZHAO Hui CHEN Li SUN Qiang REN Shan LIU Mao-lun YANG Han TANG Shun LU Jin-jian XU Hai-bo 
National Natural Science Foundation of China(81573813,81173598);Sichuan Provincial Admin⁃istration of Traditional Chinese Medicine of China(2021MS447);the Excellent Talent Program of Chengdu University of Traditional Chinese Medicine of China(YXRC2019002,ZRYY1917);Open Research Fund of the State Key Labora⁃tory of Southwestern Chinese Medicine Resources of China(2020XSGG006)。
OBJECTIVE To investigate the therapeutic effect of scutellarin on colitis-associated cancer(CAC)and its underlying mechanism based on Wnt/β-catenin signaling pathway.METHODS The mouse model of CAC was established by ...
关键词：SCUTELLARIN colorectal cancer Wnt signaling pathway AOM/DSS 
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