Cardiopulmonary,complications in chronic liver disease  

作　　者：SφrenMφller JensHHenriksen 

机构地区：[1]Department of Clinical Physiology,239,Hvidovre Hospital,University of Copenhagen,Copenhagen,Denmark

出　　处：《World Journal of Gastroenterology》2006年第4期526-538,共13页世界胃肠病学杂志（英文版）

摘　　要：Patients with cirrhosis and portal hypertension exhibit characteristic cardiovascular and pulmonary hemodynamic changes. A vasodilatatory state and a hyperdynamic circulation affecting the cardiac and pulmonary functions dominate the circulation. The recently defined cirrhotic cardiomyopathy may affect systolic and diastolic functions, and imply electromechanical abnormalities. In addition, the baroreceptor function and regulation of the circulatory homoeostasis is impaired. Pulmonary dysfunction involves diffusing abnormalities with the development of the hepatopulmonary syndrome and portopulmonary hypertension in some patients. Recent research has focused on the assertion that the hemodynamic and neurohumoral dysregulation are of major importance for the development of the cardiovascular and pulmonary complications in cirrhosis. This aspect is important to take into account in the management of these patients.有肝硬化和门静脉高血压的病人展出典型心血管、肺的血液动力学的变化。一个 vasodilatatory 状态和影响心脏、肺的功能的亢奋的动态发行量统治发行量。最近定义的肝脏硬化症的心肌症可以影响收缩、心脏舒张的功能，并且暗示机电的畸形。另外，循环 homoeostasis 的压力感受器功能和规定被损害。肺的机能障碍涉及在一些病人与肝肺症候群和 portopulmonary 高血压的发展传播畸形。最近的研究集中于血液动力学、神经元介质的 dysregulation 具有为在肝硬化的心血管、肺的复杂并发症的发展的主要重要性的断言。这个方面是重要的在这些病人的管理考虑。

关 键 词：CIRRHOSIS Portal hypertension CARDIOMYOPATHY HEMODYNAMICS Vasoactive substances BARORECEPTORS Hepatopulmonary syndrome Portopulmonary hypertension Autonomic dysfunction 

分 类 号：R575[医药卫生—消化系统]