Role of Baicalein in the regulation of proliferation and apoptosis in human myeloma RPMI8226 cells  

作　　者：LI Qiu-bai Y0U Yong CHEN Zhi-chao Lü Jian SHA0 Jing Z0U Ping 

机构地区：[1]Institute of Hematology, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022,China

出　　处：《Chinese Medical Journal》2006年第11期948-952,共5页中华医学杂志（英文版）

摘　　要：Multiple myeloma （MM） is a uniformly fatal disease characterized by a clonal proliferation of neoplastic plasma cells in the bone marrow and is the second most commol hematological malignancy.1 At present, a cure for multiple myeloma has not been achieved with chemotherapeutic regimen, and many patients die of drug-resistant disease. Thus, the development of new effective anticancer agents to treat both early and advanced MM seems to be an attractive perspective.Multiple myeloma （MM） is a uniformly fatal disease characterized by a clonal proliferation of neoplastic plasma cells in the bone marrow and is the second most commol hematological malignancy.1 At present, a cure for multiple myeloma has not been achieved with chemotherapeutic regimen, and many patients die of drug-resistant disease. Thus, the development of new effective anticancer agents to treat both early and advanced MM seems to be an attractive perspective.

关 键 词：BAICALEIN 12-lipoxygenase PROLIFERATION APOPTOSIS 

分 类 号：R733.3[医药卫生—肿瘤]