戈佐岛的家族性假性脱皮  

Familial pseudoexfoliation in Gozo

作　　者：Hardie J.G. Mercieca F. Fenech T. Cuschieri A. 王海燕 

机构地区：[1]Department of Ophthalmology,St. Luke'sHospital, G'Mangia, Malta

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第5期27-28,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Aims: To describe the occurrence of pseudoexfoliation in three Gozitan families. Methods: Three families with a high incidence of pseudoexfoliation were identified. All members of the three families who agreed to participate were interviewed and underwent a full ophthalmologic examination. The pseudoex-foliation status was classified as present, absent, or unknown. Results: A total of 55 individuals from three separate family probands and with a male:female sex ratio of 5:4 were examined. In all, 18 had definite evidence of pseudoexfoliation, 17 of them bilaterally and one showing only unilateral signs. Age was the main risk factor, with 18 out of the 20 individuals who were over the age of 60 years having pseudoexfoliation, while none of the 35 who were below the age of 60 years had pseudoexfoliation. The ophthalmological findings varied in different families. Family I had a high incidence of both cataract and glaucoma, family II had mainly glaucoma, while in family III all individuals had cataract but none had evidence of glaucoma. The first generation of these three families were deceased but their hospital and clinical records revealed that in all three families the father was affected and there was no evidence of maternal involvement. Conclusions: In all three families, pseudoexfoliation appeared to be genetically transmitted as a late onset autosomal dominant trait of variable expression. Maternal transmission could not be confirmed in these families.Aims： To describe the occurrence of pseudoexfoliation in three Gozitan families. Methods： Three families with a high incidence of pseudoexfoliation bers of the three families who were identified. All memagreed to participate were interviewed and underwent a full ophthalmologic examination. The pseudoex- foliation status was classified as present, absent, or unknown. Results： A total of 55 individuals from three separate family probands and with a male： female sex ratio of 5： 4 were examined. In all, 18 had definite evidence of pseudoexfoliation, 17 of them bilaterally and one showing only unilateral signs. Age was the main risk factor, with 18 out of the 20 individuals who were over the age of 60 years having pseudoexfoliation.

关 键 词：家族性 脱皮 假性 眼部检查 高发家族 危险因素 家族成员 眼部表现 60岁 先证者 

分 类 号：R174[医药卫生—妇幼卫生保健] R770.4[医药卫生—公共卫生与预防医学]