基于诺西肽分批发酵的过程建模  

Mathematical Modeling of Batch Fermentation Process for Nosiheptide

作　　者：张大鹏[1] 王福利[1] 何建勇[2] 何大阔[1] 林志玲[1] 常玉清[1] 

机构地区：[1]东北大学信息科学与工程学院,沈阳110004 [2]沈阳药科大学制药工程学院,沈阳110016

出　　处：《系统仿真学报》2006年第8期2311-2313,2330,共4页Journal of System Simulation

基　　金：国家自然科学基金(60374003);973计划子课题(2002CB312200);教育部及辽宁省流程工业综合自动化重点实验室开放基金(PAL200509)

摘　　要：诺西肽是一种含硫多肽类抗生素,该抗生素能明显促进动物生长,而且在动物体内无残留,是一种优良的非吸收型饲料添加剂。以分批发酵工艺过程为对象,研究了基质浓度、抑制物及菌体自身浓度对菌体生长的影响,建立了诺西肽的菌体生长模型、基质消耗模型、产物生成模型,以及溶解氧与操作变量(搅拌转速和通气量)的关联模型。在所建模型基础上,对诺西肽的分批发酵过程进行了仿真研究,仿真结果与实验结果基本一致。Nosiheptide, a novel type of sulfur-containing peptide antibiotics, is a perfect un-assimilated feed additive which can promote animal growth and has no residual in animal body. The influence of substrate, inhibitor and biomass on the microbial living was studied by modeling. The key models included the biomass growth model, the substrate consumption model and the production model. The relation between dissolved oxygen and operation variables （agitating speed and ventilation）, which is an important factor in nosiheptide batch fermentation process, was investigated by mechanism. The adequacy of the proposed models is proved through simulation.

关 键 词：生化工程 建模 分批发酵 诺西肽 溶解氧 

分 类 号：TP391.9[自动化与计算机技术—计算机应用技术]