Hypoxic imaging with ^(99m)Tc-HL91 single photon emission computed tomography in advanced nonsmall cell lung cancer  

作　　者：LI Ling YU Jin-ming XING Li-gang YANG Guo-ren SUN Xin-dong XU Jin ZHU Hui YUE Jin-bo 

机构地区：[1]Department of Radiation Oncology, Shandong Cancer Hospital andInstitute, Ji＇nan 250117, China [2]Department of Nuclear Medicine, Shandong Cancer Hospital andInstitute, Ji＇nan 250117, China [3]Tianjin Medical University, Tianjin 300070, China

出　　处：《Chinese Medical Journal》2006年第17期1477-1480,共4页中华医学杂志（英文版）

基　　金：This study was sponsored by grants from the National Natural Science Foundation of China(No.30371381);Key Projects Foundation of Department of Science and Technology of Shandong province(No.031050102).

摘　　要：Tumoural hypoxia can influence response to radiotherapy and other treatments, and oxygenation status has proved to be a prognostic indicator of the outcome of radiotherapy.1 Therefore, it is important to assess tumoural hypoxia and reoxygenation before selection of treatment protocols. During the last two decades, much attention has been paid to noninvasive imaging techniques using radiolabelled markers for the detection of hypoxic cells in solid tumours.2 Technetium （^99mTc） is a very convenient isotope for use with such imaging because it is readily available and suited to routine clinical use.Tumoural hypoxia can influence response to radiotherapy and other treatments, and oxygenation status has proved to be a prognostic indicator of the outcome of radiotherapy.1 Therefore, it is important to assess tumoural hypoxia and reoxygenation before selection of treatment protocols. During the last two decades, much attention has been paid to noninvasive imaging techniques using radiolabelled markers for the detection of hypoxic cells in solid tumours.2 Technetium （^99mTc） is a very convenient isotope for use with such imaging because it is readily available and suited to routine clinical use.

关 键 词：lung neoplasm RADIOTHERAPY HYPOXIA 

分 类 号：R734.2[医药卫生—肿瘤]