透明质酸高产菌种选育及发酵条件优化  

Microbial mutant screen for high hyaluronic acid production and optimization for fermentation conditions

作　　者：吴小刚[1] 胡家俊[1] 薛海燕[1] 

机构地区：[1]湖北工业大学生物工程学院,湖北武汉430068

出　　处：《中国酿造》2006年第9期30-32,共3页China Brewing

摘　　要：用NTG和LiCl复合诱变,筛选不产溶血素和透明质酸降解酶的突变菌株,对发酵条件进行优化,在最佳发酵条件下,透明质酸的产量达到5.68g/L,分子量达到1.06×106Da。By the treatment with NTG and LiCI, a mutant strain was obtained owning the ability to produce high amount of hyaluronic acid without the production of hemolysin or hyaluronidase. After the optimization on fermentation conditions, 5.68 g/L hyaluronic acid was produced with molecular weight of 1.06× 10^6.

关 键 词：透明质酸 马链球蔺 发酵 

分 类 号：Q93[生物学—微生物学]