GLI基因与肢体发育相关性的研究进展  

Advances in the Research of Correlation of GLI Gene with Limb Development

作　　者：张炫[1] 金春莲[1] 

机构地区：[1]中国医科大学医学遗传学教研室,沈阳110001

出　　处：《国际遗传学杂志》2006年第5期393-396,共4页International Journal of Genetics

基　　金：国家重点基础研究发展规划(NO.2001CB510301);国家自然科学基金(NO.30471803)

摘　　要：在肢体发育中,Sonic hedgehog(SHH)蛋白作为极化区(the zone of polarizing actiVity,ZPA)的调节因子,发挥着十分重要的作用。然而SHH是如何沿着肢体的前后轴发挥调控作用的还不是很清楚。最近的报道表明SHH主要是通过阻止转录因子GLI3裂解成抑制形式发挥作用,而后者也能够关闭SHH靶基因的表达。GLI基因家族的成员编码含有锌指结构的转录因子,主要对SHH的靶基因发挥调节作用。现就GLI基因在肢体发育中的表达特点及其临床意义进行综述。During the development of the limb, Sonic hedgehog（SHH） protein plays a key role as a mediator of the zone of polarizing activity （ZPA）. However, the molecular mechanisms by which SHH directs anterior/posterior patterning in the limb remain unknown. It is recently reported that SHH produces main effect by preventing transcription factor GLI3 from cleaving into a repressor form, and the latter can close the expression of SHH target genes. Members of GLI gene family encode zinc-finger transcription factors which can regulate the SHH target genes. In this review we would like to summarize the expressional feature and clinical significance of GLI genes in limb development.

关 键 词：GLI 多指 突变 SHH 肢体发育 

分 类 号：Q344[生物学—遗传学]