鱼粉延缓高脂血症大鼠慢性肾衰的发展  

Fish meat retarding the progression of chronic renal failure in spontaneously hypercholesterolemic rats

作　　者：梁向明[1] 大谷晴久 

机构地区：[1]山东大学齐鲁医院泌尿内科,济南250012 [2]日本和歌山县立医科大学肾病与血液净化中心

出　　处：《卫生研究》2006年第6期727-730,共4页Journal of Hygiene Research

基　　金：佳林豪基金2005年资助项目

摘　　要：目的对比鱼粉和干酪素为蛋白质来源的饮食对自然发生高脂血症(SHC)大鼠慢性肾衰发展的不同影响。方法48只10周龄的SHC大鼠随机分为4组,分别给予含20%、40%鱼蛋白或酪蛋白的饮食饲育至22周龄,每4周检测血压、尿液和血液生化学改变,肾脏于实验结束时用于组织学和免疫组织化学检查。结果与同比例的酪蛋白相比,进食鱼粉为蛋白质来源的SHC大鼠均显示出较少的尿蛋白排泄量、较慢的肾功能下降速率和较轻的肾组织损伤程度。结论与干酪素相比,以鱼粉为蛋白质来源的饮食延缓了SHC大鼠慢性肾衰的发展速度。Objective To investigate the effects of different dietary proteins of fish meat and casein upon the progression of chronic renal failure （CRF） in spontaneously hypercholesterolemic （SHC） rats. Methods 48 SHC rats of 10 weeks of age were randomly divided into four groups, and placed on diets containing 20% and 40% casein or fish protein respectively till they were 22 weeks of age. 24-hour urine collections were obtained along with measurements of systolic blood pressure and blood were drew from their tail vein every 4 weeks. Finally, the kidneys were removed and prepared for histological and immunohistochemistry study. Results Fish meat diet slowed the progression of proteinuria, renal function failure and glomerular injury compared with the control casein diet in both 20% and 40% dietary groups. Conclusion Fish meat retarded the progression of CRF in SHC rats compared with casein.

关 键 词：低蛋白饮食 鱼蛋白 鱼油 高脂血症 慢性肾衰竭 

分 类 号：TS254.51[轻工技术与工程—水产品加工及贮藏工程] R155.3[轻工技术与工程—食品科学与工程]