青少年抑郁症患者性激素受体基因微卫星多态性与功能失调性认知的关系  

Association of Gonadal Receptor Genes′ Microsatellites and Dysfunctional Attitudes in Adolescent with Major Depressive Disorder

作　　者：苏巧荣[1] 王长虹[2] 耿耀国[3] 任光圆[4] 陈青[5] 

机构地区：[1]绍兴文理学院医学院附属医院心理科,浙江绍兴312000 [2]新乡医学院第二附属医院,河南新乡453000 [3]郑州大学教育学院应用心理学系,郑州450000 [4]绍兴文理学院医学院,浙江绍兴312000 [5]绍兴文理学院医学院附属医院检验科,浙江绍兴312000

出　　处：《实用儿科临床杂志》2006年第24期1711-1712,1726,共3页Journal of Applied Clinical Pediatrics

基　　金：浙江省自然科学基金项目资助(Y204412)

摘　　要：目的探讨青春期首发的青少年抑郁症患者性激素受体基因微卫星多态性是否与功能失调性认知存在联系。方法采用聚合酶链式反应(PCR)结合毛细管电泳和基因扫描技术,检测青春期首发的青少年抑郁症患者雄激素受体(AR)、雌激素受体α(ERα)、雌激素受体β(ERβ)基因重复序列多态性的重复片段长度。应用《功能失调性态度问卷》(DAS)对青少年抑郁症患者进行评估,并把评估结果和微卫星多态片段长度进行相关性和对照性分析。结果1.女性患者ERβ基因微卫星多态性与DAS总分呈显著负相关;2.对各位点等位基因分长短片段作组间比较,发现ERα短片段组DAS总分显著高于长片段组。男性患者不存在这种差异性。3.AR受体与功能失调性认知不存在这种联系。结论女性青少年ERα、ERβ受体基因微卫星多态可能与功能失调性认知存在联系,而男性青年抑郁症患者可能不存在这种联系。Objective To explore the associations between microsatellites in gonadal receptor genes and dysfunctional attitudes in adolescent with major depressive disorder （MDD）. Methods Polyrnerase chain reaction（PCR） ,capillary electrophoresis and genetic scanning were performed in testing the length of microsatellites in first- onset adolescent depressive patients. Dysfunctional attitudes scale （DAS） was used in rating the dysfunctional cognition of adolescent depressive sample. These results were tested by correlative analysis and com- parison analysis. Results 1. There existed significantly negative correlation between rnicrtellite＇s length in estrogen receptor β（ERβ） gene and total score of DAS in female adolescent patients with first onset depressive disorder. 2. DAS＇ total score of shorter alleles＇ group was significantly higher than that of longer alleles＇ group on female＇ estrogen receptor a（ERa） Gene, Conclusion The microsatellite＇s length of ERα and ERβ gene may have associations with dysfunctional attitudes of female adolescent with MDD.

关 键 词：雄激素受体基因 雌激素α受体基因 雌激素β受体基因 青少年 重性抑郁症 功能失调性态度 

分 类 号：R749.4[医药卫生—神经病学与精神病学]