Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carrier via dendritic approach  

作　　者：Juan Huang Jian Wei Wang Tao Gong Zhi Rong Zhang 

机构地区：[1]Key Laboratory of Drug Targeting, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

出　　处：《Chinese Chemical Letters》2007年第3期247-250,共4页中国化学快报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （No. 30430770）.

摘　　要：To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.

关 键 词：INSULIN 5-FLUOROURACIL PRODRUG Characterization Stability 

分 类 号：R979.1[医药卫生—药品]