抗菌肽的生物活性、作用机制及应用研究进展  

Bioactivity,action mechanism and application of antimicrobial peptides

作　　者：赵喜红[1] 何小维[1] 罗志刚[1] 

机构地区：[1]华南理工大学轻工与食品学院,广东广州510640

出　　处：《中国酿造》2007年第4期1-5,共5页China Brewing

基　　金：广东省科技攻关项目(2006B40101013)

摘　　要：抗菌肽是具有抗菌活性的一类短肽,广泛存在于生物界,是先天免疫的重要防御物质,具有广谱抗菌活性和抗病毒、抗真菌、抗寄生虫及抗肿瘤等生物活性,且不易产生抗药性,有良好的应用前景。该文对抗菌肽的生物活性、作用机理及应用现状进行了综述,并指出在开发研究抗菌肽中存在的问题,对其发展作了展望。Antimicrobial peptides （AMPs）, a family of short-chain peptides with antibacterial activity, are widely spread in biological universe. AMPs are important defense substances in innate immune system. Except for broad-spectrum antibacterial activity, AMPs have more biological activities on the resistance of virus, fungi, parasite and tumor, but scarcely induce drug resistance, which defines a great application prospect. In this paper, the bioactivity, action mechanism and application of AMPs were summarized. Moreover, the current problems and future development were prospected.

关 键 词：抗菌肽 生物活性 作用机制 应用 

分 类 号：TQ465[化学工程—制药化工]