番石榴多糖对糖尿病小鼠的血糖及抗氧化能力的影响  

Effects of guava polysaccharides on blood glucose level and antioxidant activity in diabetic mice

作　　者：吴建中[1] 欧仕益[1] 陈静[2] 郭开平[1] 欧亦群[1] 

机构地区：[1]暨南大学食品科学与工程系,广东广州510632 [2]暨南大学医学院营养教研室,广东广州510632

出　　处：《中成药》2007年第5期668-671,共4页Chinese Traditional Patent Medicine

基　　金：暨南大学启动基金资助(项目号51204011)

摘　　要：目的:观察番石榴多糖对四氧嘧啶诱导的糖尿病小鼠血糖及抗氧化水平的影响。方法:通过对小鼠腹腔注射四氧嘧啶建立糖尿病小鼠模型,将小鼠分成5组:正常对照组、糖尿病对照组、番石榴多糖Ⅰ组、番石榴多糖Ⅱ组、格列苯脲组。在给小鼠灌胃多糖3 d和10 d后,采用血糖仪检测小鼠血糖值,第10日麻醉处死小鼠,分别检测小鼠血清和肝脏中的SOD和MDA水平。结果:与糖尿病对照组比较,灌喂番石榴多糖的两组小鼠的血糖值均较低,同时两组小鼠的血清及肝脏中的T-SOD含量较高,MDA含量较低。结论:番石榴多糖能够显著降低糖尿病小鼠血糖,提高其抗氧化能力,是一种潜在的糖尿病治疗药物。AIM： To study the effects of guava polysaccharides on blood glucose level and antioxidant activity in alloxan-induced diabetic mice. METHODS： The animal model of diabetes was established by injecting alloxan into mice abdominal cavity. The mice were divided into five groups： normal control group, diabetic model group, guava polysaccharides group Ⅰ, guava polysaccharides group Ⅱ, glybenclamide group. Blood glucose level was determined with blood glucose monitor 3 d and 10 d after being given polysaccharides. The mice were anaesthetized and killed on the tenth day. Activity of SOD and concentration of MDA in blood serum and liver were determined. RESULTS： Compared with diabetic model group, the blood glucose level of guava polysaccharides group Ⅰ and guava polysaccharides group Ⅱ significantly decreased. Activity of T-SOD in blood serum and liver significantly increased, while concentration of MDA in blood serum and liver significantly decreased. CONCLUSION： Guava polysaccharides can significantly decrease blood glucose level and improve the antioxidant activity of diabetic mice. It is a potential hypoglycemic agent.

关 键 词：番石榴 多糖 降血糖作用 抗氧化 

分 类 号：R258.6[医药卫生—中医内科学]