抗癫痫药物对血中同型半胱氨酸、叶酸、维生素B_(12)浓度的影响  

Effect of anti-epileptic drugs on the blood levels of homocysteine,folate and vitaminB12

作　　者：王小花[1] 张同霞[2] 赵秀鹤[1] 高静[1] 刘学伍[1] 迟兆富[1] 

机构地区：[1]山东大学齐鲁医院神经内科,山东济南250012 [2]山东大学医学院,山东济南250012

出　　处：《山东大学学报（医学版）》2007年第4期357-359,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨抗癫痫药物(Antiepileptic Drugs,AEDs)对血同型半胱氨酸(Homocysteine,Hcy)、叶酸、维生素B12(VitaminB12,VitB12)浓度的影响。方法:采用荧光定量法和电化学发光免疫法测定88例服用单一药物治疗的癫痫患者(服用卡马西平、苯妥英钠各30例、服用丙戊酸28例)和30例未服用AEDs的癫痫对照者及40例健康对照者血Hcy、叶酸、VitB12浓度,比较各组间差异。结果:服用卡马西平和苯妥英钠的患者血Hcy水平明显高于癫痫对照组和正常对照组(P<0.001),叶酸水平明显低于癫痫对照组和正常对照组(P<0.001),服用丙戊酸的患者血Hcy水平有下降趋势、叶酸水平有上升趋势,但与两对照组相比,差异无统计学意义。VitB12在癫痫组有下降趋势,但与两对照组相比,差异无统计学意义。结论:服用卡马西平、苯妥英钠的患者Hcy水平升高而叶酸水平降低,对这类癫痫患者适当补充叶酸、VitB12可能有益于降低心脑血管病的发病率。Objective： To investigate the effect of anti-epileptic drugs（AEDs） on the blood levels of homocysteine, folate and vitaminB12. Methods： There were 3 groups tested： （1）88 epipleptic patients, taking a single AEDs; （2）epileptic control group, 30 epileptic patients not taking AEDs; （3）normal control group, 40 healthy controls. The levels of homocysteine, folate and vitaminB12 were determined by a fluorescence quantity method and electrochemistry radiation immunity. Results： In epileptic patients taking a single carbamazepine （CBZ） and phenytoin（PHT）, the levels of homocysteine were significantly higher and the levels of folate were significantly lower than those of the control group （ P 〈 0.001）. The levels of homocysteine, folate and vitaminB12 were not significantly changed in patients taking valproic acid（VPA） （ P 〉 0.05）. Conclusions： Homocysteine levels of epileptic patients taking CBZ and PHT were significantly increased whereas the folate levels of epileptic patients taking CBZ and PHT were significantly decreased. An adequate dosage of folate and vitaminB12 for epileptic patients is helpful in preventing angiocardiopathy and cerebrovascular diseases.

关 键 词：癫痫 抗惊厥剂 同型半胱氨酸 叶酸 维生素B12 

分 类 号：R742.1[医药卫生—神经病学与精神病学]