Synaptic plasticity,AMPA-R trafficking,and Ras-MAPK signaling  

作　　者：Yun GU Ruth L STORNETTA 

机构地区：[1]Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA [2]Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

出　　处：《Acta Pharmacologica Sinica》2007年第7期928-936,共9页中国药理学报（英文版）

基　　金：Work from the Julius ZHU Laboratory is supported in part by the US Department of Defense and National Institutes of Health USA;Dr Yun GU is a visiting postdoctoral fellow supported a scholarship from the Chinese Ministry Health

摘　　要：Synaptic modification of transmission is a general phenomenon expressed at almost every excitatory synapse in the mammalian brain. Over the last three decades, much has been discovered about the cellular, synaptic, molecular, and signaling mechanisms responsible for controlling synaptic transmission and plasticity. Here, we present a brief review of these mechanisms with emphasis on the current understanding of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor （AMPA-R） trafficking and Ras-mitogen-activated protein kinase （MAPK） signaling events involved in controlling synaptic transmission.Synaptic modification of transmission is a general phenomenon expressed at almost every excitatory synapse in the mammalian brain. Over the last three decades, much has been discovered about the cellular, synaptic, molecular, and signaling mechanisms responsible for controlling synaptic transmission and plasticity. Here, we present a brief review of these mechanisms with emphasis on the current understanding of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor （AMPA-R） trafficking and Ras-mitogen-activated protein kinase （MAPK） signaling events involved in controlling synaptic transmission.

关 键 词：AMPA receptors MAPK NEUROMODULATOR NMDA receptors PLASTICITY RAS Rapl Rap2 synaptic transmission TRAFFICKING 

分 类 号：Q42[生物学—神经生物学]