转金属硫蛋白基因平菇对受辐照、衰老和铅中毒小鼠抗氧化能力的影响  

Effects on Anti-oxidezation Ability of Model Mice Fed with Transgenic Metallothionein Mushroom (Pleurotus ostreatus)

作　　者：李汉臣[1] 生吉萍[2] 徐培培[2] 刘绍军[1] 茹炳根[3] 申琳[2] 

机构地区：[1]河北科技师范学院食品工程系,河北秦皇岛066000 [2]中国农业大学食品科学与营养工程学院,北京100083 [3]北京大学生命学院,北京100871

出　　处：《食品科学》2007年第7期459-461,共3页Food Science

基　　金：国家自然科学基金项目(30200191)

摘　　要：研究了转金属硫蛋白基因平菇对不同模型小鼠抗氧化能力的影响。结果表明:在小鼠饲料中掺入1%和3.16%的转金属硫蛋白基因平菇干粉(前者相当于50～60kg体重的人每日摄食鲜菇1kg),可明显增强受辐照小鼠血清SOD活性,降低其血清MDA含量;明显增强铅中毒小鼠血清SOD活性和抗活性氧能力;对衰老小鼠血清SOD活性的降低、MDA含量的升高无明显改善作用。结论:转金属硫蛋白基因平菇可提高受辐照和铅中毒小鼠的抗氧化能力,对增强D-半乳糖致衰老模型小鼠抗氧化能力无明显效果。Objective： Effects on anti-oxidization ability of model mice fed with transgenic metallothionein（MT） mushroom were studied in this paper. The results showed that the dried transgenic MT mushroom can significantly enhance the activity of SOD and reduce MDA content of radiated mice＇s serum, and promote the activity of SOD and the ability of anti-active oxygen of lead poisoned mice when there is 1% or 3.16% MT mushroom mixed feed（the fomer corresponding to does of 1 kg/d to human whose weight is 50~60 kg）. But there is no apparent effect on activity of SOD and MDA content in senile mice＇s serum. Conclusion： Transgenic MT mushroom can evidently improve anti-oxidization ability of radiated mice and lead poisoned ones. But there is no advantageous effect on senile caused mice after intradermal injecting of D-galactose.

关 键 词：转金属硫蛋白基因平菇 小鼠 抗氧化能力 丙二醛(MDA) 超氧化物岐化酶(SOD) 

分 类 号：S646.14[农业科学—蔬菜学]