Role of iron in hepatic fibrosis: One piece in the puzzle  

作　　者：Marie A Philippe Richard G Ruddell Grant A Ramm 

机构地区：[1]Hepatic Fibrosis Group,The Queensland Institute of Medical Research,PO Royal Brisbane and Women's Hospital,Brisbane 4029,Australia

出　　处：《World Journal of Gastroenterology》2007年第35期4746-4754,共9页世界胃肠病学杂志（英文版）

基　　金：NHMRC Program Grant 339400

摘　　要：Iron is an essential element involved in various biological pathways. When present in excess within the cell, iron can be toxic due to its ability to catalyse the formation of damaging radicals, which promote cellular injury and cell death. Within the liver, iron related oxidative stress can lead to fibrosis and ultimately to cirrhosis. Here we review the role of excessive iron in the pathologies associated with various chronic diseases of the liver. We also describe the molecular mechanism by which iron contributes to the development of hepatic fibrosis.铁是涉及各种各样的生物小径的一个必要元素。什么时候在房间以内在过量介绍，铁能由于它 catalyse 的能力是有毒的损坏激进分子的形成，它支持细胞的损害和细胞死亡。在肝以内，铁联系了氧化应力能导致纤维变性并且最终到肝硬化。这里，我们在与肝的各种各样的慢性病联系的病理考察过多的铁的角色。我们也描述铁由贡献肝的纤维变性的发展的分子的机制。

关 键 词：IRON FIBROSIS Oxidative stress Hepatic stellate cell HAEMOCHROMATOSIS Hepatitis C Non-alcoholic fatty liver disease Alcoholic liver disease 

分 类 号：R575.2[医药卫生—消化系统]