猕猴桃汁抗MNNG致g12细胞gpt位点突变的研究  

SUPPRESSING EFFECTS OF KIWI FRUIT ON 6—THIOGUANINE—RESISTANT MUTATION INDUCED

作　　者：薛宏伟[1] 林慰慈[1] 徐厚恩[1] 尚兰琴[1] 

机构地区：[1]北京医科大学卫生毒理学教研室

出　　处：《癌变．畸变．突变》1997年第2期112-115,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：采用哺乳动物细胞诱发基因突变试验，研究了魁蜜种和ＦｒｕｉｔｉｎｇＭａｌｅ种猕猴桃汁对Ｎ—甲基—Ｎ’—硝基—Ｎ—亚硝基胍（ＭＮＮＧ）诱发ｇ１２细胞ｇｐｔ位点突变的拮抗作用。结果表明，两种猕猴桃汁对ＭＮ－ＮＧ的诱变性都有显著的抑制作用，进一步说明了猕猴桃抗损伤作用的广谱性，同时发现猕猴桃汁的活性成分是在细胞内发生作用的。Antimutagenicity of the two kinds of kiwi fruit(KF) was studied with 6-thioguanine-resistant mutation assay.The results showed that both Kuimi and Fruiting Male KF could significantly reduce the frequency of 6-thioguanine-resistant mutants induced in g12 cell line by MNNG,and the suppressing effects of KF functioned within cells.

关 键 词：果汁 猕猴桃汁 g12细胞 点突变 药理学 

分 类 号：TS275.5[轻工技术与工程—农产品加工及贮藏工程]