1-(5′-溴阿魏酰基)-4-苄基哌嗪盐酸盐类似物体外清除羟自由基活性研究  

Study on Hydroxyl Radical Scavenging Activities in vitro of 1-(5′-Bromo Feruloyl)-4-Benzyl Piperazine Hydrochloride Analogs

作　　者：林爱斌[1] 张鲁勉[1] 何小英[1] 郑锦鸿[1] 

机构地区：[1]汕头大学医学院化学教研室,广东汕头515041

出　　处：《汕头大学医学院学报》2008年第1期28-29,33,共3页Journal of Shantou University Medical College

摘　　要：目的：研究1-（5′-溴阿魏酰基）-4-苄基哌嗪盐酸盐类似物（BFP，L1-9）在体外清除羟自由基（·OH）的活性。方法：采用邻二氮菲-Fe^2氧化法测定BFP、阿魏酸（FA）、抗坏血酸（Vc）在体外对Fenton反应产生·OH的清除能力，计算表观清除率（CL）。结果：L5的最大·OH表观清除率（CLmax）最大，L8最小，L1、L3、L5、L7的CLmax都比FA、Vc大。结论：BFP苄基苯环上2-Cl、3-Cl、2-CH3、4-CH3、3-OCH3取代，可增强体外清除·OH活性；3-CH3取代，体外清除·OH活性基本不变；2-OCH3、4-OCH3取代，体外清除·OH活性降低。Objective： To study hydroxyl radical（·OH）scavenging activities in vitro of 1-（5′-bromo feruloyl）-4-benzyl piperazine hydrochloride analogs（BFP, L1-9）. Methods： The ·OH scavenging activities in vitro of BFP, ferulie acid （FA）and L-aseorbie acid（Vc）were analysed through 1, 10-phenanthroline-Fe^2＋ detection system. The ·OH clearance percentage（CL）was calculated. Results： L5 had the highest ·OH maximum clearance percentage（CLmax）. L8 had the lowest CLmax. L1, L3,L5 and L7 had higher CLmax than FA and Vc. Conclusion： Substitutes on benzal benzene ring of BFP have different effects on ·OH scavenging activity in vitro. 2-Cl, 3-Cl, 2-CH3, 4-CH3 and 3-OCH3 may enhance the activity. 3-CH3 may not change the activity. 2-OCH3 and 4-OCH3 may reduce the activity.

关 键 词：阿魏酸 羟自由基 FENTON反应 

分 类 号：R914[医药卫生—药物化学] R927[医药卫生—药学]