Pleiotropic effects of bombesin and neurotensin on intestinal mucosa: Not just trefoil peptides  

作　　者：Stelios F Assimakopoulos Chrisoula D Scopa Vassiliki N Nikolopoulou Constantine E Vagianos 

机构地区：[1]Department of Internal Medicine, School of Medicine, University of Patras, Patras 26110, Greece [2]Department of Pathology, School of Medicine, University of Patras, Patras 26110, Greece [3]Division of Gastroenterology, Department of Internal Medicine, School of Medicine, University of Patras, Patras 26110, Greece [4]First Surgical Department, "Saint Panteleimon" General Hospital of Nikaia, Piraeus 18454, Greece

出　　处：《World Journal of Gastroenterology》2008年第22期3602-3603,共2页世界胃肠病学杂志（英文版）

摘　　要：Bombesin and neurotensin are neuropeptides which exert a wide spectrum of biological actions on gastrointestinal tissues influencing intestinal growth and adaptation, intestinal motility, blood flow, secretion, nutrient absorption and immune response. Based mainly on their well-established potent enterotrophic effect, numerous experimental studies investigated their potential positive effect on the atrophic or injured intestinal mucosa. These peptides proved to be effective mucosa-healing factors, but the potential molecular and cellular mechanisms for this action remained unresolved. In a recently published study (World J Gastroenterol 2008; 14(8): 1222-1230), it was shown that their protective effect on the intestine in experimentally induced inflammatory bowel disease was related to anti-inflammatory, antioxidant and antiapoptotic actions. These results are in close agreement with our previous studies on jaundiced and hepatectomized rats that showed a regulatory effect of bombesin and neurotensin on critical cellular processes such as enterocyte' proliferation and death, oxidative stress and redox equilibrium, tight junctions' formation and function, and inflammatory response. The pleiotropic effects of bombesin and neurotensin on diverse types of intestinal injury may justify their consideration for clinical trials.Bombesin and neurotensin are neuropeptides which exert a wide spectrum of biological actions on gastrointestinal tissues influencing intestinal growth and adaptation, intestinal motility, blood flow, secretion, nutrient absorption and immune response. Based mainly on their well-established potent enterotrophic effect, numerous experimental studies investigated their potential positive effect on the atrophic or injured intestinal mucosa. These peptides proved to be effective mucosa-healing factors, but the potential molecular and cellular mechanisms for this action remained unresolved. In a recently published study （World J Gastroenterol 2008; 14（8）： 1222-1230）, it was shown that their protective effect on the intestine in experimentally induced inflammatory bowel disease was related to anti-inflammatory, antioxidant and antiapoptotic actions. These results are in close agreement with our previous studies on jaundiced and hepatectomized rats that showed a regulatory effect of bombesin and neurotensin on critical cellular processes such as enterocyte＇ proliferation and death, oxidative stress and redox equilibrium, tight junctions＇ formation and function, and inflammatory response. The pleiotropic effects of bombesin and neurotensin on diverse types of intestinal injury may justify their consideration for clinical trials.

关 键 词：BOMBESIN NEUROTENSIN PLEIOTROPIC NEUROPEPTIDES Regulatory peptides 

分 类 号：R574[医药卫生—消化系统]