异麦芽酮糖醇对变形链球菌生长、黏附和产酸影响的研究  

Effect of isomalt on amount,adhesion,and pH value of streptococcus mutans

作　　者：黄晨辉 王伟健[1] 杨圣辉[2] 

机构地区：[1]北京大学口腔医学院.口腔医院,北京积水潭医院100081 [2]首都医科大学口腔医学院

出　　处：《现代口腔医学杂志》2008年第4期362-364,共3页Journal of Modern Stomatology

摘　　要：目的研究异麦芽酮糖醇对变形链球菌致龋因素的影响,探讨其作用机制,为进一步的动物和人体研究提供科学依据。方法以异麦芽酮糖醇为实验组,蔗糖、木糖醇为对照组,观察异麦芽酮糖醇、蔗糖和木糖醇对变形链球菌的生长、黏附及菌液pH值的影响。结果变链在一定浓度的异麦芽酮糖醇与木糖醇培养基上生长数量均受到抑制,与蔗糖相比有显著性差异(P<0.001);其形态也有明显变化。变链在不同浓度的异麦芽酮糖醇、木糖醇培养基中黏附于附着板的数量与蔗糖有明显差异(P<0.001)。变链在不同浓度的异麦芽酮糖醇、木糖醇培养基中所测得的pH值均高于蔗糖培养基(P<0.001)。结论异麦芽酮糖醇与蔗糖相比,其作用与木糖醇相似,可以使变链形态改变、数量减少、黏附和产酸能力均减弱。Objective To investigate the potential effect of isomalt on the pathogenic factors of streptococcus mutants by a series of laboratory tests. Methods Three groups were divided that test group was isomalt based on culture mediums, two control groups were xylitol and sucrose based culture mediums, respectively. The streptococcus mutans were cultured in the three mediums in order to observe the amount, the adhesion, and the pH value in the solution. Results The amount of streptococcus mutans was less in the isomalt group than that in sucrose group, P 〈0. 001, and streptococcus mutans changed the form into smooth coccus, and extracellular polysaccharide decreased greatly in the xylitol and the isomalt group. The amount of streptococcus mutans adhered to the standard plastic strip was different between the isomalt group and the sucrose group in different concentrations （ P 〈0. 001 ）. The pH values of the streptococcus mutans solution in the isomalt group and the xylitol group were higher than those in the sucrose group at the same concentration, and the differences among the three groups were statistically significant （ P 〈 0. 001 ）. Conclusion As one of sugar substitutes, isomalt was good to control streptococcus mutants. Further studies in laboratory, animal and clinics are needed.

关 键 词：异麦芽酮糖醇 变形链球菌 蔗糖 木糖醇 

分 类 号：R151[医药卫生—营养与食品卫生学]