优生干预对染色体平衡易位携带者再次妊娠结局的影响  

The Effect of Eugenism Intervention on Re-pregnancy of Patients with Chromosome Balanced Translocation

作　　者：孙静华[1] 蔺冬菊[1] 代培凤[1] 潘力[1] 牟倩[1] 

机构地区：[1]潍坊医学院附属潍坊市人民医院遗传科,山东潍坊261041

出　　处：《潍坊医学院学报》2008年第3期242-243,共2页Acta Academiae Medicinae Weifang

摘　　要：目的探讨优生干预对染色体平衡易位携带者再次妊娠结局的影响。方法对22例染色体平衡易位携带者再次孕前行血清生殖激素水平测定、免疫抗体检测及生殖道炎症检查后，于患者再孕前后分别进行优生干预性治疗并行产前诊断。结果15例患者再次成功妊娠，其中13例（68．2％）已分娩表型正常儿，子代染色体不平衡异常率仅为31．8％，明显低于理论异常率（60％～80％）。结论优生干预可显著提高染色体平衡易位携带者再次妊娠的优生率。Objective To evaluate the effect of eugenism intervention on re-pregnancy of patients with chromosome balanced translocation. Methods The blood reproductive hormone, immune antibody and genital tract inflammation of 22 patients with chromosome balanced translocation were detected before re-pregnancy. The patients were treated with birth-defect prevention before and after pregnancy, and were received prenatal diagnosis. Results Thirteen babies among 15 patients with re-pregnancy were normal（ 68.2% ） , and the abnormal rate of babies was otdy 31.8% ,which was much lower than the academic abnormal rate （ 60% - 80% ）. Conclusion Eeugenism intervention can remarkablely increase the eugenism rate of re-pregnancy in patients with chromosome balanced translocation.

关 键 词：染色体 平衡易位 优生 干预措施 

分 类 号：R394[医药卫生—医学遗传学]