基于氨基酸特征序列的蛋白质结构分析  

Analysis of the Protein Structure based on the amino acids characteristics sequences

作　　者：朱平[1] 管维红[1] 高雷[1] 徐振源[1] 

机构地区：[1]江南大学理学院

出　　处：《生物信息学》2008年第3期106-108,116,共4页Chinese Journal of Bioinformatics

基　　金：江南大学预研基金资助(2007LYY007)

摘　　要：针对蛋白质序列中氨基酸的核苷酸组成部分及其相关特征信息,提出另外的σ-等序列的概念,并讨论了其主要特征与次要特征,可作为对蛋白质进行定性和定量比较的一种方法,用来判断这些物种的同源性和相似性程度。然后,对所取的全α螺旋,全β折叠和αβ类序列,利用σ-,τ-,στ序列的概念,给出蛋白质序列的相关氨基酸特征序列。同时对三类共18个蛋白质序列进行数值刻划,给出数值刻划图并进行分析。In this paper, by introducing the homomorphism in algebra and ＂coarse＂ in physics into consisting bases of the amino acid synonymy codon, these concepts of σ- , τ- and στ are presented for nucleofide components of amino acids in protein,and the numerical description method of relating amino acid characteristic sequences in proteins is given. By comparison of the characteristic sequences, we get some infor marion about the structural characteristic of amino acids on three kinds of secondary structural classes of proteins：all α- helix, all β- strand, and αβ kind protein, respectively. Finally, the graph representation with numerical description of amino acid characteristic sequences about 18 protein sequences is given.

关 键 词：特征序列 同义密码子 蛋白质序列 数值刻划图 

分 类 号：Q518.1[生物学—生物化学] O15[理学—数学]