Halothane hepatitis in Iran:A review of 59 cases  

作　　者：Payam Eghtesadi-Araghi Amir-Ali Sohrabpour Homayoon Vahedi Mehdi Saberi-Firoozi 

机构地区：[1]Digestive Disease Research Center, Shariati Hospital,Medical Sciences/University of Tehran [2]Gastroenterology Research Center,Shiraz University of Medical Sciences [3]Digestive Disease Research Center, Shariati Hospital, Medical Sciences/University of Tehran

出　　处：《World Journal of Gastroenterology》2008年第34期5322-5326,共5页世界胃肠病学杂志（英文版）

基　　金：A grant from the Digestive Disease Research Center,Tehran University of Medical Sciences, Iran,No.83.36

摘　　要：AIM:To study halothane hepatitis (HH) in Iran and its associated risk factors. METHODS: We retrospectively studied files of all cases diagnosed with HH referred to three referral hospitals and four private centers in Iran from April 1994 to September 2006. Information on age at surgery, gender, medications history, obesity, history of previous exposure, previous reaction to halothane, familial history, type of surgery, perioperative hypoxia or sepsis, morbidity and mortality were recorded and analyzed. RESULTS: A total of 59 cases were identifi ed. Forty- eight (81%) were women. The median age at the time of surgery was 44 years (range, 18 to 80 years). Sixty percent of patients were above 40-year-old. Obesity was observed in 22.2%. Previous history of exposures to halothane was noted in 61% of which 50% had history of post-exposure reaction. Coronary artery bypass graft (CABG), cholecystectomy, and cosmetic surgeries (mainly weight reduction) were the most frequent surgeries. The mortality rate was 12.2%. In patients developing encephalopathy, it was as high as 50%. CONCLUSION: HH remains an important cause of morbidity and mortality in centers still using this anesthetic. However, a large percentage of these casescould have been avoided. To lessen occurrence of further cases of HH, the authors suggest that in female patients having a history of surgery (or delivery) with general anesthesia, the use of halothane should be absolutely avoided. Utilization of proper substitutes in adults’ anesthesia is advocated.AIM：To study halothane hepatitis （HH） in Iran and its associated risk factors. METHODS： We retrospectively studied files of all cases diagnosed with HH referred to three referral hospitals and four private centers in Iran from April 1994 to September 2006. Information on age at surgery, gender, medications history, obesity, history of previous exposure, previous reaction to halothane, familial history, type of surgery, perioperative hypoxia or sepsis, morbidity and mortality were recorded and analyzed. RESULTS： A total of 59 cases were identifi ed. Forty- eight （81%） were women. The median age at the time of surgery was 44 years （range, 18 to 80 years）. Sixty percent of patients were above 40-year-old. Obesity was observed in 22.2%. Previous history of exposures to halothane was noted in 61% of which 50% had history of post-exposure reaction. Coronary artery bypass graft （CABG）, cholecystectomy, and cosmetic surgeries （mainly weight reduction） were the most frequent surgeries. The mortality rate was 12.2%. In patients developing encephalopathy, it was as high as 50%. CONCLUSION： HH remains an important cause of morbidity and mortality in centers still using this anesthetic. However, a large percentage of these casescould have been avoided. To lessen occurrence of further cases of HH, the authors suggest that in female patients having a history of surgery （or delivery） with general anesthesia, the use of halothane should be absolutely avoided. Utilization of proper substitutes in adults’ anesthesia is advocated.

关 键 词：ANESTHESIA INHALATION HALOTHANE HEPATITIS DRUG-INDUCED 

分 类 号：R575.1[医药卫生—消化系统]