精氨酸加压素V_1受体阻断剂对氧化震颤素引起低温反应的影响  

Effect of Arginine Vasopressin V_1 Receptor Antagonist on Oxotremoreine-induced Hypothermic Responses in the Rat

作　　者：赖雁[1] 杨永录[1] 沈字玲[1] 黄涛[1] 任佳[1] 

机构地区：[1]成都医学院基础医学院,610083

出　　处：《医学研究杂志》2008年第12期62-64,共3页Journal of Medical Research

基　　金：四川省教育厅科研基金资助项目(2007ZC011)

摘　　要：目的本研究旨在探讨内源性精氨酸加压素(AVP)是否参与M胆碱激动剂氧化震颤素(OXO)引起的低温反应。方法用无线遥测技术测量大鼠的体温和活动变化,观察腹腔注射AVPV1受体阻断剂对OXO引起的体温和活动变化的影响。结果给大鼠皮下注射OXO能引起明显的低温反应,大约4h后恢复到对照水平。腹腔注射AVPV1阻断剂可以明显阻断OXO的低温效应。结论AVPV1受体阻断剂可以阻断OXO引起的低温作用,提示OXO引起的降温效应可能是通过AVP的释放所致。Objective To Study wheather the endogenous arginine vasopressin （AVP） is involved in the effect of oxotremorine （a muscarinic receptor agonist） - induced hypothermic response. Methods Core temperature and motor activity were monitored in undisturbed rats using radiotelemetry. Effect of AVP V1 antagonist on oxotremorine （OXO） -induced changes in body temperature and motor activity were observed in the rats. Results Administration of OXO led to a marked hypothermia. Core temperature recovered to basal levels at 4 hours after OXO administration. AVP V1 antagonist blocked markedly the hypothermia effect of OXO. Conclusion The AVP V1 - receptor antagonist block the hypothermic effect of OXO ,which suggests that OXO - induced hypothermia is mediated by AVP releasing.

关 键 词：氧化震颤素 低温反应 精氨酸加压素V1受体阻断剂 

分 类 号：R363.27[医药卫生—病理学] R212[医药卫生—基础医学]