硫辛酸脂质纳米粒的制备工艺研究  

Study on Preparation of Alpha-Lipoic Acid-Loaded Lipid Nanoparticles

作　　者：夏强[1,2] 唐金国[1,2] 徐弟[1,2] 徐峰[1,2] 

机构地区：[1]东南大学生物科学与医学工程学院,江苏南京210096 [2]东南大学苏州市生物医用材料与技术重点实验室,江苏苏州215123

出　　处：《纳米科技》2008年第6期20-22,共3页

基　　金：科技部国际科技合作项目2008DFB50060;美国可口可乐公司国际合作项目的支持

摘　　要：研究了负载硫辛酸纳米乳液的高温相行为，获得其高温相图。根据相图结果，采用高压均质法制备了硫辛酸脂质纳米粒。系统研究了乳化剂配比、均质循环次数等实验参数对脂质纳米粒制备的影响，进而优化了制备条件，并通过了优化配方重复性试验的验证。光子相关谱结果表明，硫辛酸脂质纳米粒的平均粒径为214＋59nm。时间和温度稳定性测试表明，硫辛酸脂质纳米粒在两个月内具有良好的稳定性。Phase behavior of ALA-loaded hot nanoemulsion was studied and the phase diagrams were obtained. Based on phase diagram results, ALA lipid nanoparticles （LN） were prepared by High Pressure Homogenization method. The influence of surfactants, homogenization cycle numbers and other experimental parameters had been studied in details. The optimized preparation condition was confirmed and repeated. The mean size of ALA-LN was 214 59 nm which was obtained by photon correlation spectroscopy. ALA-LN showed good time and temperature stability.

关 键 词：硫辛酸 脂质纳米粒 高温纳米乳液相图 

分 类 号：R91[医药卫生—药学] TS202.3[轻工技术与工程—食品科学]