克山病区和非病区居民蛋白质营养状况与抗氧化能力的对比调查  

Protein Status and Antioxidant Capability of Residents in Endemic and Nonendemic Areas of Keshan Disease(KD)

作　　者：顾履珍[1,2] 许洁[1,2] 周燕[1,2] 田园[1,2] 王学超[1,2] 廖锡君 毛建琼 邹挽危 

机构地区：[1]中国预防医学科学院营养与食品卫生研究所 [2]四川省西昌市凉山州卫生防疫站

出　　处：《卫生研究》1998年第2期140-142,共3页Journal of Hygiene Research

基　　金：国家"八五"攻关项目

摘　　要：１９９５年从克山病区和非病区居民蛋白质营养调查中发现病区居民除血硒含量显著低于非病区居民外，血浆中胱氨酸、色氨酸和赖氨酸均显著低于非病区居民，而血浆脂质过氧化物含量则显著高于非病区居民。此结果提示克山病病区居民硒缺乏以及含硫氨基酸和色氨酸摄入不足，导致机体抗氧化能力下降，可能是引起克山病发病的一个重要因素。文中还着重讨论了含硫氨基酸在机体内抗氧化作用机理。From a survey of residents in endemic and nonendemic areas of Keshan disease(KD),it was found that the plasma cystine,tryptophan and lysine as well as blood selenium content were lower,while the plasma lipid peroxide was higher in endemic areas than those in non endemic areas.These results suggests that the selenium deficiency coexisting with cystine and tryptophan insufficiency decreases the antioxidant defense of the organism and may be one of the important factors for the development of KD.The role of sulfur containing amino acid in antioxidant defense is discussed emphatically.

关 键 词：克山病 居民 蛋白质营养 抗氧化能力 

分 类 号：R542.302[医药卫生—心血管疾病]