谷氨酰胺转氨酶研究进展  

Advancement of Research on Transglutaminases

作　　者：崔艳华[1] 张兰威[1] 

机构地区：[1]哈尔滨工业大学食品科学与工程学院,哈尔滨150090

出　　处：《生物技术通报》2009年第1期31-36,共6页Biotechnology Bulletin

基　　金：黑龙江省重点自然基金(ZJND6D5-02);黑龙江省十一五科技攻关项目(GA06B201);黑龙江省攻关项目(GA07B401)

摘　　要：谷氨酰胺转氨酶是一种催化酰基转移反应的转移酶,它可使蛋白分子间和分子内产生共价交联,从而改变蛋白的功能特性,在食品、医药、化妆品、纺织等领域具有重要的潜在应用价值。研究表明,谷氨酰胺转氨酶广泛存在于生物组织中。为了更好的研究开发这一资源,对谷氨酰胺转氨酶的来源、理化特性、作用机制、功能以及工业生产的现状进行了综述,其中重点探讨了不同来源的谷氨酰胺转氨酶在理化特性以及底物特异性方面的差异。Transglutaminase that can catalyzes an acyl transfer reaction,generates inter- and intramolecular cross-links between proteins. Due to great potential to improve various functional properties of proteins,TGase has many biotechnological applications involved particularly in food processing industry,medicine,cosmetic and textile industry. In this paper,sources,enzymatic properties,reaction mechanism and production of TGase were reviewed and enzymatic properties from various sources of TGase were discussed detailedly.

关 键 词：谷氨酰胺转氨酶 交联 蛋白修饰 底物特异性 

分 类 号：TS201.25[轻工技术与工程—食品科学]