喷雾干燥法制备诺西肽掩味微囊的研究  

Preparation of bitter masked microcapsules of nosiheptide by spray-dried process

作　　者：潘岳峰[1] 韩静[1] 杨静[1] 殷莉梅[1] 张立军[2] 何建勇[3] 

机构地区：[1]沈阳药科大学制药工程学院,沈阳110016 [2]吉林敖东延边药业股份有限公司检测中心,吉林延边133700 [3]沈阳药科大学生命科学与生物制药学院,沈阳110016

出　　处：《中南药学》2009年第2期108-111,共4页Central South Pharmacy

摘　　要：目的探索喷雾干燥法制备诺西肽微囊的最佳掩味工艺。方法以干粉得率、包封率、掩味效果、吸湿性作为指标,采用正交设计法确定最佳喷雾干燥工艺参数。结果最佳工艺参数为:进风温度185℃,进料速度600mL.h-1,压缩空气压力0.5 mPa。结论该工艺合理,诺西肽微囊质量达到预期要求,产品稳定性好,为工业化生产提供了实验依据。Objective To optimize the preparation of nosiheptide microcapsules and its bitter masked condition by spray-dried process. Methods Technology was set up in terms of hygroscopicity and yield rate of dried powders and entrapment efficiency by orthogonal experiment design. Results The optimum conditions were： the intake temperature was 185 ℃, the input speed was 600 mL · h-1 and the stored air pressure was 0.5 mPa. Coneluion The quality of nosiheptide microcapsules meets the expectation, the process is stable, and the experimental results provide the basis for mass production.

关 键 词：诺西肽 喷雾干燥 掩味 微囊 

分 类 号：R978.1[医药卫生—药品] R943[医药卫生—药学]