RNA干扰在白血病基因治疗中的研究进展  

RNAi was researched progress in leukemia gene treatment

作　　者：田彩霞[1] 王宏伟[1] 

机构地区：[1]山西医科大学第二医院血液病研究所,太原030001

出　　处：《肿瘤研究与临床》2007年第4期280-282,共3页Cancer Research and Clinic

摘　　要：RNA干扰(RNAi)是双链RNA特异抑制靶基因表达的转录后基因沉默方式,以白血病特异性融合基因和白血病广谱表达的WT1基因为靶标的siRNA治疗是白血病基因治疗的有效方式之一。然而,RNAi应用于临床仍面临许多问题有待解决。RNAi is double-strands RNA inhibiting specially target gene's expression and leads to post-transcript gene silence.SiRNA treatment targeted leukemia's fuse gene and WT1 gene which leukemia express universally,SiRNA treatment is a effective method for leukemia gene treatment.However,RNAi has lots of problems waiting for solution when it is used in clinic.

关 键 词：白血病 RNAI 融合基因 WT1 

分 类 号：R733.7[医药卫生—肿瘤]