Effects of procainamide on 0morphological parameter of dense granule and a granule in blood platelet  

作　　者：林继红 单春文 杨素勤 刘连璞 顾为望 

出　　处：《Journal of Medical Colleges of PLA(China)》1999年第2期144-148,共5页中国人民解放军军医大学学报（英文版）

摘　　要：Objective: To study the protective effect of procainamide (PA) on the ultrastructure of blood platelets.Methods:The stereology measurement was used to study the effects of PA on morphological parameters of dense granule and a granule. Results: 8. 5, 34. 0 and 136. 0 μmol· L-1 PA ascended morphological parameter values of dense granule and a granule significantly. The increasing percentages were 153. 6% ~ 256. 2% (SS ), 81. 6% ~188. 9% (Sv) and 96. 3% ~145. 4 % (St ) for surface parameter values; 144. 0% ~499. 7% (Vv) and 221. 3% ~1593. 4 % (Vt ) for volume parameter values in dense granule. In a granule, the increasing percentages were 68. 2 %~335. 9% (Nv) and 14. 8%~ 696. 0% (N) for number parameter values; 45. 4%~ 87. 5% (S), -(50.7% 57. 1 % ) (SS), 160. 3% -558. 0% (Sv ) and 181. 5%~395. 7% (St ) for surface parameter values ; 87. 8%~127. 7% (D). 81. 4 %~ 202. 3% (V), 410. 5% ~773. 6% (Vv) and 195. 8% ~297. 8% (Vt) for volume parameter values. Conclusion: PA protects dense granule and a granule from AA-stimulating changes of morphology.

关 键 词：PROCAINAMIDE arachidonic acid BLOOD PLATELET electron MICROSCOPY STEREOLOGY measllrement 

分 类 号：R96[医药卫生—药理学]