Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma  

作　　者：薛洪利 王辉 孔令权 周怀伟 

出　　处：《Chinese Medical Journal》1998年第8期79-81,共3页中华医学杂志（英文版）

摘　　要：Abstract: Objective To find an effective method for the treatment of malignant cerebral glioma by opening the bloodbrainbarrier (BBB).Methods The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bischloronitrosourea (BCNU).Results After intracarotid infusion of papaverine for reversible opening of BBB, the MTX concentration in tumor tissue was 1810±380 ng/g, higher than that in patients without papaverine infusion (997±126 ng/g). Eightynine patients with glioblastoma and 66 patients with anaplastic astrocytoma received intracarotid infusion of papaverine and BCNU (250 mg) for an [CM(23*6/8]average of 2.14 times. The mean survival time of thesepatients was 114.5 weeks, median survival time was 140 weeks, and fiveyear survival rate was 22.97%.Conclusion The combined chemotherapy with papaverine and BCNU through intraarterial infusion is simple, safe and effective in treating malignant cerebral glioma so long as the tumor is sensitive to the drugs.Abstract: Objective To find an effective method for the treatment of malignant cerebral glioma by opening the bloodbrainbarrier (BBB).Methods The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bischloronitrosourea (BCNU).Results After intracarotid infusion of papaverine for reversible opening of BBB, the MTX concentration in tumor tissue was 1810±380 ng/g, higher than that in patients without papaverine infusion (997±126 ng/g). Eightynine patients with glioblastoma and 66 patients with anaplastic astrocytoma received intracarotid infusion of papaverine and BCNU (250 mg) for an [CM(23*6/8]average of 2.14 times. The mean survival time of thesepatients was 114.5 weeks, median survival time was 140 weeks, and fiveyear survival rate was 22.97%.Conclusion The combined chemotherapy with papaverine and BCNU through intraarterial infusion is simple, safe and effective in treating malignant cerebral glioma so long as the tumor is sensitive to the drugs.

关 键 词：INFUSION PAPAVERINE intracarotid TREATMENT OPENING BLOOD-BRAIN-BARRIER 

分 类 号：R730.264[医药卫生—肿瘤]