EVALUATION OF ATRACURIUM IN MYASTHENIC PATIENTS UNDERGOING THYMECTOMY  

作　　者：黄宇光 罗爱伦 罗来葵 

机构地区：[1]PUMC Hospital,CAMS,Beijing

出　　处：《Chinese Medical Sciences Journal》1990年第2期102-106,共5页中国医学科学杂志（英文版）

摘　　要：Myasthenia gravis is an autoimmune disease involving the acetylcholine receptors atneuromuscular junctions.Perioperative management of patients with myasthenia gravis iscomplicated by their enhanced sensitivity to nondepolarizing neuromuscular blocking agentsand their resistance to depolarizing drugs (1).Prolonged respiratory depression commonlyoccurs when these agents are used.Atracurium dibesilate is one of a new series of nonde-polarizing agents and is promising by virtue of its rapid degradation by‘Hoffmann elimina-tion’.leaving products with little or no muscle blocking activity.After encouraging resultswere obtained with atracurium (2-6),we investigated the neuromuscular blocking effect ofdifferent doses of the drug (0.2 mg/kg,0.5 mg/kg) in sixteen myasthenic patients undergoingthymectomy.with continuous monitoring of neuromuscular function.Myasthenia gravis is an autoimmune disease involving the acetylcholine receptors at neuromuscular junctions.Perioperative management of patients with myasthenia gravis is complicated by their enhanced sensitivity to nondepolarizing neuromuscular blocking agents and their resistance to depolarizing drugs (1).Prolonged respiratory depression commonly occurs when these agents are used.Atracurium dibesilate is one of a new series of nonde- polarizing agents and is promising by virtue of its rapid degradation by‘Hoffmann elimina- tion’.leaving products with little or no muscle blocking activity.After encouraging results were obtained with atracurium (2-6),we investigated the neuromuscular blocking effect of different doses of the drug (0.2 mg/kg,0.5 mg/kg) in sixteen myasthenic patients undergoing thymectomy.with continuous monitoring of neuromuscular function.

关 键 词：ATRACURIUM MYASTHENIA GRAVIS 

分 类 号：R[医药卫生]