PRENATAL DIAGNOSIS OF THALASSEMIAS BY USING POLYMERASE CHAIN REACTION (PCR)  

作　　者：张基增 蔡仕萍 黄道华 王仲祥 简悦威 

机构地区：[1]The First Medical College of PLA,Guangzhou [2]Uniuersity of California,San Francisco,USA

出　　处：《Chinese Science Bulletin》1989年第15期1317-1318,共2页

摘　　要：DNA analysis has become the method of choice for diagnosis of many genetic disorders. In 1978 Kan and Dozy described the first useful restriction fragment length polymorphism (RFLP) in the β globin gene cluster which was found to be in disequilibrium strongly associated with the sickle cell anemia gene (Hb S). Based on that, they did the linkage analysis for Hb S gene and successfully made prenatal diagnosis. From then on, as genetic markers, RFLPs have been widely used for the linkage analysis and the diagnosis of genetic disorders. In 1983 oligonucleotide hy-

关 键 词：linkage length ANEMIA GLOBIN DELETION DNA SPANNING mutant PARENTS elusion 

分 类 号：N[自然科学总论]