Study progress of cell endocytosis  

细胞内吞作用的研究进展(英文)

作　　者：Li Chen Hui Li Ren Zhao jianwei Zhu 

机构地区：[1]Department of Pathology, Nantong University Medical College, Nantong 226001, China [2]Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 230002, China [3]Department of General Surgery, Affiliated Hospital, Nantong University, Nantong 226001, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2009年第6期360-365,共6页中德临床肿瘤学杂志（英文版）

基　　金：Supported by grants from the National Natural Sciences Foundation of China (No. 30771126 and 30772106)

摘　　要：Endocytosis is a process through which extracellular materials are transported into cell through membrane deformation. This process is not a simple step-by-step process in which a series of proteins function according to the chronological order, but rather a complex process comprising many members which are regulated precisely. The role of endocytosis is broadly divided into two categories, phagocytosis and pinocytosis, the latter is divided into four species in accordance with the size of endocytosis substances： clathrin dependent endocytosis, the diameter of clathrin-coated vesicle is 100-150 nm; caveolin dependent endocytosis, the diameter of caveolin protein-coated vesicle is 50-100 nm; macropinocytosis, the diam- eter of macropinocytosis is generally 0.5-2 μm, sometimes up to 5 μm; clathrin and caveolin independent endocytosis. Many proteins including endophilin A1, A2, A3, and endocytotic proteins B, B1a, and Blb as well as dynamin, actin and Rab protein families are involved in endocytosis and play an important role in different stages. The abnormal endocytosis may be involved in the development of certain diseases.

关 键 词：ENDOCYTOSIS CLATHRIN CAVEOLIN ENDOPHILIN signalling pathway 

分 类 号：R531.8[医药卫生—内科学] R817[医药卫生—临床医学]