微波辅助合成红霉素环11,12-碳酸酯  

Microwave-assisted synthesis of erythromycin cyclic 11,12-carbonate

作　　者：尹戎[1] 宋志春[1] 张志荣[1] 包凯[1] 张为革[1] 程卯生[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《中国药物化学杂志》2009年第3期218-220,共3页Chinese Journal of Medicinal Chemistry

基　　金：沈阳市科学技术计划项目(1063223-3-00)

摘　　要：在无相转移催化剂存在的条件下红霉素、碳酸乙撑酯及碳酸钾(物质的量之比为1∶5∶1.5)于溶剂二氧六环中,经微波照射直接合成了红霉素环11,12-碳酸酯,其结构经MS和1H-NMR谱确证。与常规的制备方法相比,该方法更加简便、有效。A straightforward, microwave-assisted synthesis of erythromycin cyclic 11, 12-carbonate from erythromycin A（EM） by reacting with 1,3-dioxolan-2-one and potassium carbonate（ the molar ratio of EM： 1, 3-dioxolan-2-one： carbonate was 1：5： 1.5） in dioxane was accomplished in the absence of phase transfer catalyst and its structure was characterized by MS and ^1H-NMR. The present method was proved to be more convenient and effective to obtain erythromycin cyclic 11,12-carbonate compared with conventional methods.

关 键 词：红霉素环11 12-碳酸酯 微波辅助合成 抗菌活性 

分 类 号：R914[医药卫生—药物化学]