乳铁素免疫调节功能评价  

Evaluation of Immunoregulatory Function of Lactoferricin

作　　者：胡志和[1] 刘传国[1] 庞广昌[1] 陈庆森[1] 

机构地区：[1]天津市食品生物技术重点实验室,天津商业大学生物技术与食品科学学院,天津300134

出　　处：《食品科学》2009年第15期200-204,共5页Food Science

基　　金：天津市重点科技支撑项目(07ZCKFNC00200)

摘　　要：根据我国免疫调节功能食品的评价方法,对乳铁素的免疫调节作用进行评价。在实验中,采用Balb/c小鼠建立免疫低下模型,以不同剂量(400、40、4μg/ml)乳铁素对小鼠进行灌胃实验后。分别进行免疫脏器质量、细胞免疫功能、体液免疫功能、单核-巨嗜细胞功能等指标检测。结果表明,在灌胃剂量为40μg/ml时,结果均为阳性,判定乳铁素具有增强免疫力,但与剂量有关。To understand the iinmunoregulatory function of lactoferricin, its effects on spleen index, thymus index, cellular immune response, humoral immune function and phagocytic function of mononuclear macrophage in mice with low immunity were investigated. In the present study, animal model with low immunity was established by administering Balb/c mice with cyclophosphamide （CY） by intraperitoneal injection and the mice were administered by gavage with different doses of lactoferrcin （400, 40, and 4 μg/ml）. Our study demonstrates that the administration dose of lactoferricin of 40 μ g/ml has positive effects on all of the aforementioned indexes, suggesting that lactoferricin is able to enhance the immunoregulatory function in a dosedependent manner.

关 键 词：乳铁素 免疫调节功能 灌胃 

分 类 号：R151.2[医药卫生—营养与食品卫生学]